G6PD及SRC与膀胱癌临床病理特征及预后的相关性  

Correlation of glucose-6-phosphate dehydrogenase and Src tyrosine kinase with clinicopathological characteristics and prognosis of bladder cancer

作　　者：宫剑[1] 楼文文[1] 张大贵[2] 虞海峰[3] 黄象维 李宝青 GONG Jian;LOU Wen-wen;ZHANG Da-gui;YU Hai-feng;HUANG Xiang-wei(Department of Laboratory Medicine,the Second Affiliated Hospital of Wenzhou Medical University,Zhejiang 325027,China;不详)

机构地区：[1]温州医科大学附属第二医院检验医学学科,浙江325027 [2]温州医科大学附属第二医院病理科 [3]温州医科大学附属第二医院泌尿外科 [4]不详

出　　处：《中国卫生检验杂志》2023年第19期2405-2409,共5页Chinese Journal of Health Laboratory Technology

基　　金：浙江省医药卫生科技计划项目(2019KY460);温州市基础性科技项目(Y20180107);浙江省自然科学基金(LY20H200003)。

摘　　要：目的 探索葡萄糖-6-磷酸脱氢酶(glucose-6-phosphate dehydrogenase, G6PD)及Src酪氨酸激酶(Src tyrosine kinase, SRC)与膀胱癌患者临床病理特征及预后的相关性。方法 收集温州医科大学附属第二医院泌尿外科2012年12月—2018年12月的123例膀胱癌患者癌组织石蜡切片标本,免疫组化法检测组织中G6PD及SRC的表达情况,分析其与临床病理特征及预后的相关性。结果 60个月的随访周期内,32.52%(40/123)的患者发生全因死亡,5年总生存率为67.48%。56.91%(70/123)的患者出现复发,5年无复发生存率为43.09%。所有死亡患者的中位生存时间为40(28.25,48.50)个月,所有复发患者生存期中位数为24(16.00,33.50)个月。高表达G6PD组和SRC组患者的总生存曲线以及无复发生存曲线均低于低表达组,生存时间均短于低表达组,进行log-rank检验,差异均有统计学意义(P<0.01)。多因素Cox分析显示,高表达G6PD与总生存率(HR=3.658,P=0.003)及无复发生存率(HR=2.091,P=0.016)相关。高表达SRC与总生存率(HR=3.665,P=0.002)及无复发生存率(HR=3.086,P<0.001)相关。结论 在膀胱癌中高表达的G6PD及SRC与患者的不良预后密切相关。G6PD及SRC有望成为判断膀胱癌预后的重要生物学参考指标。Objective This paper aims to explore the correlation of glucose-6-phosphate dehydrogenase(G6PD)and Src tyrosine kinase(SRC)with the clinicopathological features and prognosis of bladder cancer.Methods The paraffin sections of 123 bladder cancer patients from December 2012 to December 2018,together with the expression of G6PD and SRC in tissues,were detected by immunohistochemistry,and the correlation with clinicopathological characteristics and prognosis was analyzed.Results During 60 months of follow-up,32.52%(40/123)of the patients had all-cause death,and the 5-year overall survival rate was 67.48%.Recurrence occurred in 56.91%(70/123)of the patients,and the 5-year recurrence-free survival rate was 43.09%.The median survival time for all deceased patients was 40(28.25,48.50)months,and the median survival for all relapsed patients was 24(16.00,33.50)months.The overall survival curve and recurrence-free survival curve of the high G6PD and SRC groups were lower than the low expression groups and shorter than the low expression groups.The log-rank test was performed and the difference was statistically significant(P<0.01).Multivariate Cox analysis showed that high expression of G6PD was associated with overall survival(HR=3.658,P=0.003)and relapse-free survival(HR=2.091,P=0.016).High expression of SRC was associated with overall survival(HR=3.665,P=0.002)and relapse-free survival(HR=3.086,P<0.001).Conclusion The high expression of G6PD and SRC in bladder cancer is closely related to the poor prognosis.G6PD and SRC are expected to be important biological reference indicators to determine the prognosis of bladder cancer.

关 键 词：膀胱癌 葡萄糖-6-磷酸脱氢酶 SRC酪氨酸激酶 临床病理特征 预后 

分 类 号：R446[医药卫生—诊断学]