钙化对甲状腺乳头状癌超声引导射频消融疗效的影响  

Effect of Calcification on the Ultrasound-Guided Radiofrequency Ablation of Papillary Thyroid Carcinoma

作　　者：李伊铭 阎琳 肖静 张明博 罗渝昆 LI Yiming;YAN Lin;XIAO Jing;ZHANG Mingbo;LUO Yukun(Department of Ultrasound,The First Medical Center of Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院第一医学中心超声诊断科,北京100853

出　　处：《中国医学科学院学报》2023年第5期803-808,共6页Acta Academiae Medicinae Sinicae

摘　　要：目的 探讨钙化对甲状腺乳头状癌(PTC)超声引导射频消融疗效的影响。方法 回顾性分析2018年1月1日至2021年12月31日在中国人民解放军总医院第一医学中心超声诊断科首次行射频消融(RFA)治疗的164例PTC患者(182个结节)的术前及随访资料,以RFA术后12个月消融灶未完全消失为终点事件,采用单因素Logistic回归筛选消融灶未完全消失的影响因素,并纳入多因素Logistic回归,分析消融灶未完全消失的独立危险因素。结果 PTC结节最大径(OR=1.16,95%CI=1.04~1.29,P=0.009)、钙化占比>2/3(OR=19.27,95%CI=4.02~92.28,P<0.001)是RFA术后12个月消融灶是否消失的影响因素。结论 伴有钙化的PTC可行超声引导下RFA治疗,当钙化占比≤2/3时与无钙化结节消融疗效相当。Objective To investigate the effect of calcification on the ultrasound-guided radiofrequency ablation(RFA)of papillary thyroid carcinoma(PTC).Methods We retrospectively analyzed the preoperative and follow-up data of 164 patients(182 nodules)with PTC treated by percutaneous ultrasound-guided RFA in the First Medical Center of Chinese PLA General Hospital from January 1,2018 to December 31,2021.The tumor status 12 months after RFA was taken as the endpoint event.The univariate Logistic regression analysis was employed to predict the influencing factors of incomplete ablation.The factors were then included in the multivariate Logistic regression analysis for prediction of the independent risk factors of incomplete ablation.Results The maximum nodule diameter(OR=1.16,95%CI=1.04-1.29,P=0.009)and calcification ratio>2/3(OR=19.27,95%CI=4.02-92.28,P<0.001)were the factors influencing the disappearance of lesion 12 months after RFA.Conclusions PTC with calcification can be treated with ultrasound-guided RFA.In the case of calcification ratio≤2/3,this therapy demonstrates the effect equivalent to that of no calcification.

关 键 词：甲状腺乳头状癌 超声 射频消融 钙化 

分 类 号：R445.1[医药卫生—影像医学与核医学] R736.1[医药卫生—诊断学]