外泌体在支气管哮喘发病机制中的研究进展  

Research Progress in Exosomes in the Pathogenesis of Bronchial Asthma

作　　者：黄丽丽 汪俊[2] HUANG Lili;WANG Jun(Department of Medicine,Graduate School of Nanchang University,Nanchang 330006,China;The Second Department of Respiratory Disease,Jiangxi Provincial People’s Hospital(The First Affiliated Hospital of Nanchang Medical College),Nanchang 330006,China)

机构地区：[1]南昌大学研究生院医学部,南昌330006 [2]江西省人民医院、南昌医学院第一附属医院二部呼吸与危重症医学科,南昌330006

出　　处：《中国医学科学院学报》2023年第5期827-832,共6页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(82160006);江西省主要学科学术和技术带头人资助计划(2017BCB22025);江西省自然科学基金面上项目(2020BAB206003)。

摘　　要：支气管哮喘是由多种免疫细胞和结构细胞共同参与的慢性气道炎症为特征的异质性疾病,具有气流受限、高反应性以及气道重塑等特征,且发病机制非常复杂。近年来,外泌体领域的研究发展迅速,外泌体是由多种细胞分泌的小囊泡,且天然存在于各种生物流体中,具有稳定、生物相容等特性。不同细胞来源的外泌体通过特定的作用机制参与气道炎症、气道重塑、气道高反应性等病理生理过程,在支气管哮喘的多个环节起到重要的调节作用。本文就外泌体在支气管哮喘发病机制中的作用做一综述。Bronchial asthma is a heterogeneous chronic inflammatory disease involving multiple immune cells and structural cells.It is characterized by airflow limitation,airway hyperresponsiveness,and airway remodeling,with complex pathogenesis.In recent years,the research on exosomes has developed rapidly.Exosomes are small vesicles secreted by a variety of cells and are naturally found in various biological fluids,with stability and biocompatibility.Exosomes from different cells are involved in pathophysiological processes such as airway inflammation,remodeling,and hyperresponsiveness through specific mechanisms and play a regulatory role in multiple links in bronchial asthma.This review focuses on the role of exosomes from different cells in the pathogenesis of bronchial asthma.

关 键 词：外泌体 哮喘 免疫效应细胞 肺结构细胞 

分 类 号：R562.25[医药卫生—呼吸系统]