基于倾向值匹配的2型糖尿病患者不同性别中体成分与甲状腺功能的相关性分析  

Correlation analysis of body composition and thyroid function in different genders of T2DM based on propensity score matching

作　　者：张若 张春虹[1] 丁石梅[1] 焦杨[1] 龙俊宏[1] 徐静[1] ZHANG Ruo;ZHANG Chunhong;DING Shimei;JIAO Yang;LONG Junhong;Xu Jing(Department of Endocrinology,The Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,China)

机构地区：[1]西安交通大学第二附属医院内分泌科,陕西西安710004

出　　处：《西安交通大学学报（医学版）》2023年第6期930-937,共8页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省自然科学基础研究计划(No.2022JQ-887);西安交通大学第二附属医院院基金自由探索(No.2020YJ(ZYTS)446)项目资助。

摘　　要：目的探讨不同性别甲状腺功能正常的2型糖尿病患者中人体体成分与甲状腺功能指标的相关性。方法研究对象为2016年2月—2018年9月在西安交通大学第二附属医院内分泌科住院的甲状腺功能正常的2型糖尿病患者,采用生物电阻抗分析法进行人体体成分分析,并进行甲状腺功能指标(FT3、FT4、TSH)的检验。应用倾向值匹配法将男性及女性研究对象按照2∶1的比例进行匹配,运用统计学分析相关性,分别在不同性别中研究体成分与甲状腺功能指标的相关性。结果男性患者中,基础代谢率、躯干脂肪质量、去脂质量、去脂质量指数、骨质质量、水分质量、肌肉质量、骨骼肌质量、骨骼肌质量指数与FT3呈正相关(P<0.05);女性患者中,脂肪质量百分比、脂肪质量指数与FT3及TSH水平呈正相关(P<0.05),去脂质量百分比、水分质量百分比、肌肉质量百分比与FT3及TSH水平呈负相关(P<0.05),基础代谢率与FT4呈负相关(P<0.05)。结论在甲状腺功能正常的2型糖尿病患者中,男性与女性体成分与甲状腺功能指标的相关性存在差异,男性中仅FT3与基础代谢率、躯干脂肪质量、去脂相关体成分有正向相关性;女性中FT3及TSH水平与脂肪相关体成分呈正相关,而与去脂相关体成分呈负相关。Objective To investigate the correlation between body composition and thyroid function indicators in type 2 diabetic patients with euthyroidism of different genders.Methods Type 2 diabetic patients with euthyroidism who were hospitalized in the Endocrinology Department of The Second Affiliated Hospital of Xi’an Jiaotong University from February 2016 to September 2018 were enrolled in this study.Bioelectric impedance analysis was used to measure body composition,and the thyroid function indicators(FT3,FT4,and TSH)were tested.The male and female subjects were matched according to the ratio of 2:1 using the propensity score matching method,and the correlation between body composition and thyroid function indicators was studied in different genders by correlation analysis.Results The basal metabolic rate,trunk fat mass,fat-free mass,fat-free mass index,bone mass,water mass,total body muscle mass,skeletal muscle mass,and skeletal muscle index were positively correlated with FT3 in male patients(P<0.05).The percentage of body fat mass and fat mass index were positively correlated with FT3 and TSH(P<0.05),and the percentages of lean mass,water mass,and total body muscle mass were negatively correlated with FT3 and TSH(P<0.05),and the basal metabolic rate was negatively correlated with FT4(P<0.05)in female.Conclusion In euthyroid type 2 diabetic patients,the correlation between body composition and thyroid function indicators are different between males and females.In males,only FT3 is positively correlated with basal metabolic rate,trunk fat mass,and fat free-related composition;while in females,both FT3 and TSH are positively correlated with fat-related composition,but negatively correlated with fat-free-related composition.

关 键 词：2型糖尿病 甲状腺功能正常 甲状腺激素 体成分分析 倾向值匹配 

分 类 号：R581.9[医药卫生—内分泌]