血清Sestrin2、Dickkopf-1与冠心病患者冠状动脉病变程度和不良心血管事件的关系  

Relationship between serum Sestrin2,Dickkopf-1 and the severity of coronary artery lesions and the occurrence of adverse cardiovascular events in patients with coronary heart disease

作　　者：方帆 周明敏[2] 许卫攀 Fang Fan;Zhou Mingmin;Xu Weipan(Department of Geriatrics,Huangshi Central Hospital of E-Dong Medical Group(Affiliated Hospital of Hubei Institute of Technology),Huangshi 435000,China;Department of Cardiovascular,Huangshi Central Hospital of E-Dong Medical Group(Affiliated Hospital of Hubei Institute of Technology),Huangshi 435000,China)

机构地区：[1]鄂东医疗集团黄石市中心医院(湖北理工学院附属医院)老年科,黄石435000 [2]鄂东医疗集团黄石市中心医院(湖北理工学院附属医院)心血管科,黄石435000

出　　处：《心脑血管病防治》2023年第9期28-31,共4页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

摘　　要：目的探讨血清Sestrin2、Dickkopf-1(DKK1)在冠心病患者冠状动脉病变程度以及不良心血管事件发生的关系。方法收集2019年1月1日至2022年3月31日鄂东医疗集团黄石市中心医院心血管科收治的153例冠心病患者作为冠心病组,年龄、性别相匹配的109例门诊体检者作为对照组。根据冠状动脉造影Gensini评分将冠心病组分为轻度病变组51例(Gensini评分≤40分)、中度病变组69例(Gensini评分41~79分)和重度病变组33例(Gensini评分≥80分)。检测血清Sestrin2、DKK1水平,出院随访不良心血管事件发生情况。结果冠心病组血清Sestrin2、DKK1水平高于对照组(t=21.075、33.941,P<0.05),重度病变组血清Sestrin2、DKK1水平高于中度病变组和轻度病变组(P<0.05)。Gensini积分、Sestrin2、DKK1是冠心病患者发生不良心血管事件的危险因素[OR(95%CI)=3.762(2.069~6.840)、1.669(1.198~2.324)、1.831(1.245~2.694),P<0.05]。联合Sestrin2、DKK1预测冠心病患者发生不良心血管事件的曲线下面积高于单独指标(Z=5.023、5.963,P<0.05)。结论冠心病患者血清Sestrin2、DKK1水平增高,且与冠状动脉病变严重程度以及不良心血管事件有关,两者联合时对冠心病患者不良心血管事件的发生有预测价值。Objective To investigate the relationship between Sestrin2 and Dickkopf-1(DKK1)levels and the severity of coronary artery lesions and the occurrence of adverse cardiovascular events in patients with coronary artery heart disease(CHD).Methods A total of 153 patients with CHD admitted to the department of cardiovascular in Huangshi Central Hospital of E-Dong Medical Group from January 1,2019 to March 31,2022 were enrolled as the CHD group,and 109 out-patients undergoing physical examinations matched by age and sex were selected as the control group.According to the Gensini score of coronary angiography,the CHD group was divided into mild lesion group(Gensini score≤40,51 cases),moderate lesion group(Gensini score 41-79,69 cases)and severe lesion group(Gensini score≥80,33 cases).Serum levels of Sestrin2 and DKK1 were measured,and adverse cardiovascular events after discharge were recorded during follow-up.Results Serum levels of Sestrin2 and DKK1 in the CHD group were higher than those in the control group(t=21.075,33.941;P<0.05),and serum levels of Sestrin2 and DKK1 in the severe lesion group were higher than those in the moderate and the mild lesion group(P<0.05).Gensini score and levels of Sestrin2 and DKK1 were risk factors for adverse cardiovascular events in patients with CHD[OR(95%CI)=3.762(2.069-6.840),1.669(1.198-2.324),1.831(1.245-2.694);P<0.05].The area under the curve of combined Sestrin2 and DKK1 predicted adverse cardiovascular events in patients with CHD was higher than that of single index(Z=5.023,5.963;P<0.05).Conclusion Elevated serum levels of Sestrin2 and DKK1 are associated with the severity of coronary artery lesions and the occurrence of adverse cardiovascular events in CHD patients.Combination of the two biomarkers has a predictive value for adverse cardiovascular events in patients with CHD.

关 键 词：冠心病 冠状动脉病变程度 不良心血管事件 Sestrin2 DICKKOPF-1 

分 类 号：R541.4[医药卫生—心血管疾病]