E3泛素连接酶在神经系统发育过程中的调控作用  

The regulatory role of E3 ubiquitin ligase in the development of the nervous system

作　　者：邓德剑 王巍巍 唐伟博 申景岭[1,3] 张喜梅 DENG De-jian;WANG Wei-wei;TANG Wei-bo;SHEN Jing-ling;ZHANG Xi-mei(Department of Histology and Embryology,Harbin Medical University,Harbin 150081;Foshan Women and Children Hospital Affiliated to Southern Medical University,Foshan 528000;Wenzhou University,Wenzhou 325035,China)

机构地区：[1]哈尔滨医科大学组织学与胚胎学教研室,黑龙江哈尔滨150081 [2]南方医科大学附属佛山妇幼保健院,广东佛山528000 [3]温州大学生命科学研究院,浙江温州325035

出　　处：《解剖科学进展》2023年第4期443-446,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(31671252);黑龙江省留学归国人员科学基金项目(LC2015028);黑龙江省博士后科研启动金(LBH-Q15084)。

摘　　要：泛素化在细胞代谢、蛋白质定位和降解中发挥着重要作用,并参与细胞周期调控、增殖、凋亡以及DNA损伤修复等生命活动的调控。泛素蛋白酶体系统(Ubiquitin proteasome system,UPS)中包括一类E3泛素连接酶(E3 ubiquitin ligase),它与泛素和底物蛋白的结合密切相关。神经系统发育是一个连续且复杂的过程,包括神经细胞发生、分化和迁移等过程,E3泛素连接酶通过水解病理性蛋白,激活神经干细胞并调节其增殖分化水平及调控神经元形态等途径来调控神经发育过程。Ubiquitination plays an important role in cellular metabolism,protein localization and degradation,and participates in the regulation of cell cycle,proliferation and apoptosis,DNA damage repair and other vital activities.E3 ubiquitin ligase(a type of ubiquitin proteasome)is related to the ability of ubiquitin and substrate protein binding.E3 ligases regulate neurogenesis progress(neural differentiation,neuronal migration and etc)via hydrolyzing pathological protein,activating neural stem cells,regulating their proliferation and differentiation level as well as regulating neuron morphology.

关 键 词：泛素蛋白酶体系统 神经系统发育 细胞代谢 DNA损伤修复 神经干细胞 神经发育 细胞周期调控 蛋白质定位 

分 类 号：R338[医药卫生—人体生理学]