肿节风抗肿瘤临床疗效及其作用机制研究进展  

Research progress in anti‑tumor clinical efficacy and mechanism of action of Sarcandrae Herba

作　　者：周冰霞 华桦 刘梅[1] ZHOU Bingxia;HUA Hua;LIU Mei(Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Sichuan Institute for Translational Chinese Medicine,Chengdu,Sichuan 610041,China)

机构地区：[1]上海中医药大学,上海201203 [2]四川省中医药转化医学中心,四川成都610041

出　　处：《上海中医药杂志》2023年第11期85-89,共5页Shanghai Journal of Traditional Chinese Medicine

基　　金：四川省科学技术厅科研院所科技成果转化项目(2023JDZH0004);四川省中医药管理局中医药科技产业创新团队专项(2022C009)。

摘　　要：综述肿节风抗肿瘤临床疗效及其作用机制的研究进展。临床研究表明,肿节风具有良好的抗肿瘤作用,配合化学疗法和放射治疗应用可发挥增效减毒的作用。体内外实验研究发现,肿节风对消化道肿瘤、呼吸道肿瘤、乳腺癌等具有细胞毒性和肿瘤抑制作用。其抗肿瘤作用机制主要与抑制细胞增殖、诱导细胞凋亡、抑制细胞端粒酶活性、抑制细胞侵袭和迁移等有关。This article reviews the research progress in the clinical efficacy and mechanism of action of Zhongjiefeng(Sarcandrae Herba)in anti-tumor treatment.Clinical studies have shown that Zhongjiefeng(Sarcandrae Herba)has a strong anti-tumor effect and can enhance the efficacy and reduce toxicity when used in combination with chemotherapy and radiation therapy.In vitro and in vivo studies have shown that Zhongjiefeng(Sarcandrae Herba)has cytotoxic and tumor inhibitory effects on digestive tract tumors,respiratory tract tumors,breast cancer,etc.Its anti-tumor mechanism is primarily associated with inhibiting cell proliferation,inducing cell apoptosis,inhibiting telomerase activity,and suppressing cell invasion and migration.

关 键 词：肿节风 抗肿瘤 中药 临床疗效 作用机制 研究进展 

分 类 号：R285[医药卫生—中药学]