单羧酸转运蛋白1在动物体内的转运调控机制  

Transport Regulation Mechanism of MonocarboxylateTransporter 1 in Animals

作　　者：张佳俐 代鹏 姜雅慧[2] 李江凌[3] ZHANG Jiali;DAI Peng;JIANG Yahui;LI Jiangling(Key Laboratory of University in Cattle Low Carbon Breeding and Safety Production in Sichuan Province,Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,China;College of Animal Science and Technology,Sichuan Agricultural University,Chengdu 611130,China;Sichuan Animal Science Research Institute,Chengdu 610066,China)

机构地区：[1]四川农业大学动物营养研究所,四川省牛低碳养殖与安全生产高校重点实验室,成都611130 [2]四川农业大学动物科技学院,成都611130 [3]四川省畜牧科学研究院,成都610066

出　　处：《动物营养学报》2023年第10期6227-6236,共10页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金(31802086);四川省自然科学基金(2022NSFSC1637);动物遗传育种四川省重点实验室开放基金课题。

摘　　要：单羧酸转运蛋白1(MCT1)是动物体内最重要的单羧酸转运蛋白亚型,广泛分布于动物体的各个组织细胞中,通过参与乳酸、短链脂肪酸等单羧酸物质的跨膜转运,发挥着多种生物学功能,包括参与营养物质转运、调节pH、作为癌症治疗的靶点、调控葡萄糖代谢平衡等。本文就近年研究,总结了MCT1在单胃和反刍动物体内的定位分布、表达差异,并重点阐述了MCT1通过转运单羧酸发挥的生物学功能和转运调控机制,为MCT1在动物体内的调控机制研究提供参考。Monocarboxylate transporter 1(MCT1)is the most important monocarboxylate transporter subtype in animals,widely distributed in all tissues and cells of animals,and plays a variety of biological functions by participating in the transmembrane transport of monocarboxylate substances such as lactic acid and short-chain fatty acids.These include involvement in nutrient transport,regulation of pH,as a target for cancer treatment,regulation of glucose metabolic balance,etc.Based on recent studies,this paper summarized the differences in the localization,distribution and expression of MCT1 in monogastric and ruminant animals,and focused on the biological function of MCT1 through the transport of monocarboxylic acid and the current transport regulation mechanism,so as to provide a reference for the study of the regulation mechanism of MCT1 in animals.

关 键 词：单羧酸转运蛋白1 生物学功能 转运调控 表达差异 

分 类 号：S811.3[农业科学—畜牧学]