植物活性成分诱导动物细胞自噬的研究进展  

Research Progress of Autophagy Induced by Plant Active Ingredients in Animal Cells

作　　者：李菲菲 童津津 方洛云 蒋林树 LI Feifei;TONG Jinjin;FANG Luoyun;JIANG Linshu(Key Laboratory of Dairy Nutrition in Beijing,College of Animal Science and Technology,Beijing University of Agriculture,Beijing 102206,China)

机构地区：[1]北京农学院动物科学技术学院,奶牛营养学北京市重点实验室,北京102206

出　　处：《动物营养学报》2023年第10期6237-6246,共10页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：北京农学院学位与研究生教育改革与发展项目(2023YJS028);北京农学院2022分类发展定额项目-人才引进启动经费(5066516005/004);BAIC05-2022。

摘　　要：动物机体健康与生产性能、畜产品安全及经济效益密切相关。自噬调节是一种非常重要的细胞修复机制,是通过清除错误折叠的蛋白质、损伤的细胞器以及入侵动物机体的病原微生物进行高度保守的一种自我消化过程。自噬调节在维持动物机体健康方面起着重要作用,失调的自噬调节与各种疾病的发生相关。植物活性成分对生命机体具有生理调节作用,堪比天然的“药房”,可通过调控不同信号通路介导自噬而减轻炎症反应,改善细胞基质代谢,提高机体免疫状态。本文围绕自噬调节的分子机制及其对动物机体健康的影响和植物活性成分对自噬的调节作用进行综述,以期为动物疾病防治提供新思路和新选择。Animal health is closely related to production performance,safety of livestock products,and economic benefits.Autophagy regulation is an important cell repair mechanism,and it is a highly conservative self-digestion process by removing misfolded protein,damaged organelles and pathogenic microorganisms invading animal bodies.Autophagy regulation plays a major role in maintaining animal health,and dysfunctional autophagy regulation is associated with the occurrence of various diseases.Plant active ingredients have a physiological promoting effect on the organisms,comparable to natural“pharmacies”,which can alleviate inflammatory reactions,improve cell matrix metabolism,as well as improve the immune status by autophagy on that regulating different signal pathways.This review aims at the molecular mechanism of autophagy regulation,and its impact on animal health,as well as the plant active ingredients on autophagy,with a novel avenue for providing new ideas and options for animal disease prevention and treatment.

关 键 词：植物活性成分 自噬调节 动物健康 

分 类 号：S963[农业科学—水产养殖]