骨髓间充质干细胞移植与血管性痴呆的相关研究进展  

Research Progress of Bone Marrow Mesenchymal Stem Cells Transplantation and Vascular Dementia

作　　者：丁帅 余佩珊 江美玲 徐宏[2] DING Shuai;YU Peishan;JIANG Meiling;XU Hong(Guangxi University of Traditional Chinese Medicine,Nanning 530000,China;Department of Encephalopathy,the Third Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Liuzhou 545000,China)

机构地区：[1]广西中医药大学,南宁530000 [2]广西中医药大学第三附属医院脑病科,广西柳州545000

出　　处：《医学综述》2022年第21期4234-4238,共5页Medical Recapitulate

基　　金：国家自然科学基金(81760413);柳州市科技计划项目(2019DH10605);广西壮族自治区中医药管理局自筹经费科研课题(GXZYZ20210318)。

摘　　要：血管性痴呆是一种神经认知障碍,也是痴呆症的第二大常见原因,严重影响患者的日常生活和精神状态。骨髓间充质干细胞(BMSCs)是一种具有自我更新和多向分化潜能的干细胞,因其体外扩增的可能性和简便性而受到越来越多的关注。BMSCs移植后可向脑组织迁移并分化为神经元样细胞和胶质细胞,同时修复损伤的胆碱能通路、增强突触的可塑性,改善患者的认知功能。因此,BMSCs移植可能成为未来治疗血管性痴呆的一种安全、有效的方法。Vascular dementia is a neurocognitive disorder and the second most common cause of dementia,which seriously affects the daily life and mental state of the patients.Bone marrow mesenchymal stem cells(BMSCs)are self-renewing stem cells with multi-directional differentiating potentials,which have attracted more and more attention because of their possibility and convenience of expansion in vitro.BMSCs can migrate to brain tissue and differentiate into neuron-like cells and glial cells after transplantation.At the same time,it can repair the injured cholinergic pathway,enhance synaptic plasticity and improve the cognitive ability of the patients.Therefore,BMSCs transplantation may become a safe and effective method for the treatment of vascular dementia in the future.

关 键 词：血管性痴呆 骨髓间充质干细胞 细胞移植 

分 类 号：R749.13[医药卫生—神经病学与精神病学]