蛋白质组学技术在脊柱结核研究中的应用  

Application of Proteomics Technology in Study of Spinal Tuberculosis

作　　者：娄才立 马宏宝 王超然 杨宗强[2] 俞梦楚 牛宁奎[3] LOU Caili;MA Hongbao;WANG Chaoran;YANG Zongqiang;YU Mengchu;NIU Ningkui(Clinical Medical College,Ningxia Medical University,Yinchuan 750004,China;Department of Orthopedics,General Hospital of Ningxia Medical University,Yinchuan 750004,China;Institute of Medical Sciences,General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学临床医学院,银川750004 [2]宁夏医科大学总医院骨科,银川750004 [3]宁夏医科大学总医院医学科学研究院,银川750004

出　　处：《医学综述》2022年第24期4803-4808,共6页Medical Recapitulate

基　　金：国家自然科学基金(81860395);宁夏自然科学基金(2020AAC03391);宁夏回族自治区重点研发计划项目(2022BEG03099)。

摘　　要：脊柱结核是一种慢性隐匿传染性疾病,早期诊断不及时、病因及致病机制尚未明确是导致脊柱结核治疗延迟及并发症发生的主要原因。蛋白质组学技术在医学领域中通过对差异蛋白的纯化、分析、表征、定量、序列、结构及生物信息学分析来探究疾病的诊断性标志物、疫苗生产研发及致病机制等。但蛋白质组学技术在脊柱结核中的相关研究较少。因此,对蛋白质组学的各种研究方法及在脊柱结核中的相关研究进行总结,可能为脊柱结核的诊治提供新思路。Spinal tuberculosis is a chronic insidious infectious disease.Missed timely early diagnosis,unclear etiology and pathogenesis,are the main reasons for the delayed treatment and complications of spinal tuberculosis.Proteomics technology explores the diagnostic markers of diseases,vaccine production and development and pathogenesis through the purification,analysis,characterization,quantification,sequence,structure and bioinformatics analysis of differential proteins of diseases in the field of medicine.However,there are few studies on proteomics technology in spinal tuberculosis.Therefore,a summary of proteomics research methods and related studies in spinal tuberculosis may provide new ideas for its diagnosis and treatment.

关 键 词：脊柱结核 蛋白质组学 生物标志物 发病机制 

分 类 号：R529.2[医药卫生—内科学] R446.11[医药卫生—临床医学]