IFN-γ/IL-4表达水平与重症肺炎支原体肺炎患儿肺功能及影像学表现的相关性  

IFN-γ/IL-4 Expression Level and Lung Function and Imaging Findings in Children with Severe Mycoplasma Pneumoniae Pneumonia

作　　者：李明月[1] 王燕[2] 詹文娟 LI Mingyue;WANG Yan;ZHAN Wenjuan(Department of Emergency,,Xi′an Children′s Hospital,Xi′an 710003,China;.Department of Neurology,Xi′an Children′s Hospital,Xi′an 710003,China)

机构地区：[1]西安市儿童医院急诊科,西安710003 [2]西安市儿童医院神经内科,西安710003

出　　处：《医学综述》2022年第24期4971-4975,共5页Medical Recapitulate

摘　　要：目的分析γ干扰素(IFN-γ)/白细胞介素(IL)-4表达水平与重症肺炎支原体肺炎患儿肺功能及影像学表现的相关性。方法选取2018年5月至2021年5月西安市儿童医院急诊科收治的87例重症肺炎支原体肺炎患儿作为研究组,选取同期就诊的69例轻症支原体肺炎患儿作为对照组。两组患儿均行胸部CT检查,比较两组患儿IFN-γ/IL-4、肺功能指标[第一秒用力呼气量(FEV_(1))、用力肺活量(FVC)、呼气流量峰值(PEF)、FEV_(1)/FVC]、胸部影像学评分,采用Pearson相关性分析IFN-γ/IL-4水平与肺功能指标及胸部影像学评分的相关性。结果研究组患儿IFN-γ、IL-4水平高于对照组[(976±99)ng/L比(590±80)ng/L、(672±81)ng/L比(294±40)ng/L](P<0.01),IFN-γ/IL-4低于对照组(1.47±0.38比2.01±0.31)(P<0.01)。研究组患儿FEV_(1)、FVC、PEF、FEV_(1)/FVC水平均低于对照组[(1.5±0.3)L比(2.1±0.4)L、(2.1±0.4)L比(2.5±0.5)L、(70±10)%比(93±13)%、(71.2±5.5)%比(84.8±5.3)%](P<0.01),胸部影像学评分高于对照组[(8.35±1.16)分比(5.24±1.01)分](P<0.01)。Pearson相关性分析结果显示,IFN-γ和IL-4与FEV_(1)、FVC、PEF、FEV_(1)/FVC均呈负相关(P<0.01);IFN-γ/IL-4与FEV_(1)、FVC、PEF、FEV_(1)/FVC均呈正相关(P<0.01);IFN-γ、IL-4与胸部影像学评分呈正相关(P<0.01);IFN-γ/IL-4与胸部影像学评分呈负相关(P<0.01)。结论重症肺炎支原体肺炎患儿IFN-γ/IL-4水平呈异常升高状态,其水平与患儿肺功能指标及胸部影像学评分密切相关,可作为评估支原体肺炎患儿病情的参考指标。Objective To analyze the correlation of interferon-γ(IFN-γ)/interleukin(IL)-4 expression levels with pulmonary function and imaging findings in children with severe Mycoplasma pneumoniae pneumonia.Methods A total of 87 children with severe Mycoplasma pneumoniae pneumonia admitted to the Department of Emergency of Xi′an Children′s Hospital from May 2018 to May 2021 were included as a research group,and 69 children with mild Mycoplasma pneumonia treated during the same period were included as a control group.Both groups of children underwent chest CT examination,and the IFN-γ/IL-4,pulmonary function indexes[forced expiratory volume in first second(FEV_(1)),forced vital capacity(FVC),peak expiratory flow(PEF)and FEV_(1)/FVC],and chest imaging scores were compared between the two groups.Pearson correlation analysis method was used to analyze the correlation of IFN-γ/IL-4 levels with lung function indexes and chest imaging scores.Results The levels of IFN-γand IL-4 in the research group were higher than those in the control group[(976±99)ng/L vs(590±80)ng/L,(672±81)ng/L vs(294±40)ng/L](P<0.01),IFN-γ/IL-4 was significantly lower than that in the control group(1.47±0.38 vs 2.01±0.31)(P<0.01).The FEV_(1) and FVC,PEF,FEV_(1)/FVC levels of the research group were lower than those of the control group[(1.5±0.3)L vs(2.1±0.4)L、(2.1±0.4)L vs(2.5±0.5)L,(70±10)%vs(93±13)%,(71.2±5.5)%vs(84.8±5.3)%](P<0.01),the chest imaging score was higher than that of the control group(8.35±1.16 vs 5.24±1.01)(P<0.01).Pearson correlation analysis showed that IFN-γand IL-4 were negatively correlated with FEV_(1),FVC,PEF and FEV_(1)/FVC(P<0.01).IFN-γ/IL-4 was positively correlated with FEV_(1),FVC,PEF and FEV_(1)/FVC(P<0.01).IFN-γand IL-4 were positively correlated with chest imaging scores(P<0.01).IFN-γ/IL-4 was negatively correlated with chest imaging scores(P<0.01).Conclusion The level of IFN-γ/IL-4 is abnormally elevated in children with severe Mycoplasma pneumoniae pneumonia,and its level is closely related to

关 键 词：支原体肺炎 重症 肺功能 γ干扰素/白细胞介素-4 影像学表现 

分 类 号：R725.6[医药卫生—儿科]