甲基化易感基因在子宫内膜异位症发生过程中的作用  

The Role of Methylation-sensitive Genes in the Development of Endometriosis

作　　者：刘玲利 李全喜 孙文霞[2] 苗聪秀[1,4] LIU Lingli;LI Quanxi;SUN Wenxia;MIAO Congxiu(Department of Reproductive Genetics,Heping Hospital Affiliated to Changzhi Medical College,Changzhi 046000,China;Department of Gynecology,Heping Hospital Affiliated to Changzhi Medical College,Changzhi 046000,China;Department of Comparative Biosciences,University of Illinois at Urbana-Champaign,Urbana 61802,USA;Key Labrotory of Reproduction Engineer of Shanxi Health Committee,Changzhi 046000,China)

机构地区：[1]长治医学院附属和平医院生殖遗传科,山西长治046000 [2]长治医学院附属和平医院妇科,山西长治046000 [3]伊利诺伊大学厄巴纳香槟分校生命科学系,伊利诺伊州厄巴纳61802 [4]山西省卫健委生殖工程重点实验室,山西长治046000

出　　处：《医学综述》2023年第3期430-437,共8页Medical Recapitulate

基　　金：国家自然科学基金(31971073);山西省应用基础研究计划项目(201901D111325)。

摘　　要：子宫内膜异位症(EMT)是一种雌激素依赖性疾病,由于孕激素对雌激素具有拮抗作用,常被用于缓解疼痛和缩小病灶。许多患者会对孕激素的刺激反应产生抵抗,但具体作用机制目前尚未明确,而DNA的甲基化可能与子宫内膜中孕激素的反应有关。目前已从子宫内膜中筛选出许多甲基化易感基因,这些基因在内膜中正常表达对维护子宫生理功能十分重要,其甲基化异常与EMT及不孕症的发生发展密切相关。因此,深入研究甲基化易感基因在EMT中的作用,有助于揭示孕激素抵抗产生的分子基础,为疾病的治疗提供新思路。Endometriosis(EMT)is an estrogen-dependent gynecologic disease.Progesterone is often used to alleviate the endometriosis pain and shrink lesions because of its antagonistic effect on estrogen.Many endometriosis patients are resistant to the stimulatory response to progesterone,although the specific molecular mechanism remains unclear,and DNA methylation may be associated with the progesterone responsiveness in the endometrium.A number of methylation-sensitive genes are currently identified from the endometrium,which play critical roles in the maintaineance of the physiological functions of endometrium,and their abnormal methylation is often associated with the occurrence and development of EMT and infertility.Hence,further investigation of methylation-sensitive genes in EMT will help us to better understand the molecular basis of progesterone resistance and provide new therapeutic ideas for the disease.

关 键 词：子宫内膜异位症 孕激素抵抗 甲基化易感基因 

分 类 号：R711.71[医药卫生—妇产科学]