MAPK信号通路与骨质疏松症关系的研究进展  

Research Progress in Relationship between MAPK Signaling Pathway and Osteoporosis

作　　者：张振南[1] 张智海 于潼[2] 李玉彬[2] 沈凌[2] 白杨[2] ZHANG Zhennan;ZHANG Zhihai;YU Tong;LI Yubin;SHEN Ling;BAI Yang(Department of Medical Affairs,Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Department of Orthopedics,Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院医务处,北京100053 [2]中国中医科学院广安门医院骨科,北京100053

出　　处：《医学综述》2023年第5期871-876,共6页Medical Recapitulate

摘　　要：骨质疏松症(OP)的根本原因在于骨吸收和骨形成的失衡,其各种防治手段均是基于多种细胞的各信号通路及相应因子调控成骨细胞、破骨细胞的自身行为,从而维持骨矿物质稳态和强度,故阐明各信号通路的潜在机制具有重要意义。作为介导细胞内外刺激信号的重要转导通路,促分裂原活化的蛋白激酶(MAPK)信号通路可控制各种细胞的活动,在调控成骨细胞和破骨细胞增殖、分化、凋亡中发挥重要作用,因此深入探讨MAPK信号通路在OP发生中的作用,可为OP的预防及治疗提供参考依据。The fundamental cause of osteoporosis(OP)is the imbalance between bone resorption and bone formation.The prevention and treatment methods all aim to regulate the behavior of osteoblast and osteoclasts based on various signaling pathways and corresponding factors of various cells,so as to maintain the homeostasis and strength of bone minerals.Therefore,it is of great significance to clarify the potential mechanisms of each signaling pathway.As an important transduction pathway mediating intracellular and extracellular stimulation signals,mitogen-activated protein kinase(MAPK)signaling pathway plays an important role in controlling various cell activities,and regulating the proliferation,differentiation and apoptosis of osteoblasts and osteoclasts.Therefore,an in-depth study of the role of MAPK signaling pathway in the occurrence of OP can provide reference for the prevention and treatment of OP.

关 键 词：骨质疏松症 促分裂原活化的蛋白激酶 信号通路 

分 类 号：R589.5[医药卫生—内分泌]