自拟宁心活血祛痰方结合阿司匹林对急性冠脉综合征经皮冠状动脉介入治疗术后血清亲环素A水平的影响  

Effects of self-made Ningxin Huoxue Qutan Decoction combined with Aspirin on serum cyclophilin A level after percutaneous coronary intervention in acute coronary syndrome

作　　者：康永 陈明 王平 Kang Yong;Chen Ming;Wang Ping(Department of Internal Medicine of TCM,Yumen Hospital of Traditional Chinese Medicine,Yumen 735211,China;Department of Critical Care Medicine,Yumen Hospital of Traditional Chinese Medicine,Yumen 735211,China)

机构地区：[1]玉门市中医医院中医内科,玉门735211 [2]玉门市中医医院重症医学科,玉门735211

出　　处：《国际中医中药杂志》2023年第10期1222-1226,共5页International Journal of Traditional Chinese Medicine

摘　　要：目的探讨自拟宁心活血祛痰方结合阿司匹林对急性冠脉综合征(ACS)经皮冠状动脉介入治疗(PCI)术后患者血清亲环素A(CyPA)水平的影响。方法随机对照试验研究。选取2017年2月-2022年1月本院142例患者作为观察对象,采用随机数字表法分为2组,每组71例。对照组口服阿司匹林,观察组在对照组基础上服用自拟宁心活血祛痰方。2组均治疗8周。分别于治疗前后以彩色超声诊断仪检测左室射血分数(LVEF)、左心室收缩末期容积指数(LVESVI)及室壁运动积分指数(WMSI);采用ELISA法检测血清血管生成素样蛋白2(Angptl2)、超敏C反应蛋白(hs-CRP)、MMP-9、亲环素A(CyPA)及髓过氧化物酶(MPO)水平,放射免疫法检测血清内皮素-1(ET-1)、MDA、SOD水平,硝酸盐还原酶法检测NO水平;评价临床疗效。结果观察组总有效率为92.96%(66/71)、对照组为80.28%(57/71),2组比较差异有统计学意义(χ^(2)=4.92,P=0.027)。观察组治疗后LVEF高于对照组(t=2.19,P<0.05),LVESVI低于对照组(t=3.13,P<0.01);血清hs-CRP、MMP-9、CyPA、MDA、Angptl2水平低于对照组(t值分别为2.44、2.20、2.08、2.10、2.35,P<0.05),SOD活力高于对照组(t=2.66,P<0.05),NO水平高于对照组(t=2.66,P<0.05)。结论自拟宁心活血祛痰方结合阿司匹林可降低ACS患者PCI术后血清亲环素A水平,,改善患者心功能及血管内皮功能,抑制机体炎性应激反应,提高临床疗效。Objective To explore the effects of self-made Ningxin Huoxue Qutan Decoction combined with Aspirin on the level of serum cyclophilin A(CyPA)in patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI).Methods Randomized controlled trial.A total of 142 patients in the hospital from February 2017 to January 2022 were selected as the participants by randomized controlled trial design,and they were divided into the two groups by the random number table method,with 71 in each group.The control group was given oral administration of Aspirin while the observation group was treated with self-made Ningxin Huoxue Qutan Decoction on the basis of the control group.Both groups were treated for 8 weeks.The left ventricular ejection fraction(LVEF),left ventricular end-systolic volume index(LVESVI)and wall motion score index(WMSI)were measured by color ultrasonic diagnostic instrument before and after treatment.The levels of serum angiopoietin-like protein 2(Angptl2),hypersensitive C-reactive protein(hs-CRP),MMP-9,CyPA and myeloperoxidase(MPO)were detected by ELISA.Serum endothelin-1(ET-1),MDA and SOD levels were detected by radioimmunoassay.Nitrate reductase was used to detect NO level,and the clinical efficacy was evaluated.Results The total effective rate in observation group was 92.96%(66/71)and that in control group was 80.28%(57/71)(χ^(2)=4.92,P=0.027).After treatment,the LVEF in observation group was significantly higher than that of the control group(t=2.19,P<0.05)while the LVESVI was significantly lower than that of the control group(t=3.13,P<0.01).The levels of serum hs-CRP,MMP-9,CyPA,MDA and Angptl2 were significantly lower than those in the control group(t=2.44,2.20,2.08,2.10,2.35,P<0.05),and the SOD activity was significantly higher than that of the control group(t=2.66,P<0.05),and the level of NO was significantly higher than that of the control group(t=2.66,P<0.05).Conclusion Self-made Ningxin Huoxue Qutan Decoction combined with Aspirin for patients with ACS after PCI can reduce the

关 键 词：急性冠脉综合征 经皮冠状动脉介入治疗 自拟宁心活血祛痰方 亲环素A 

分 类 号：R541.4[医药卫生—心血管疾病]