八正散加减结合中药熏蒸治疗难治性尿路感染阴虚湿热证的临床研究  

Clinical study of Bazheng Powder combined with traditional Chinese medicine fumigation in the treatment of Yin deficiency and damp-heat syndrome of refractory urinary tract infection

作　　者：刘伟[1] 张建中[2] 彭怀文[2] 台小东 徐庆[2] Liu Wei;Zhang Jianzhong;Peng Huaiwen;Tai Xiaodong;Xu Qing(Department of Emergency Medicine/General Medicine,Lu'an Hospital of Traditional Chinese Medicine,Lu'an 237006,China;Department of Emergency Medicine/Critical Care Medicine,Lu'an Hospital of Traditional Chinese Medicine,Lu'an 237006,China)

机构地区：[1]六安市中医院急诊科/全科医学科,六安237006 [2]六安市中医院急诊科/重症医学科,六安237006

出　　处：《国际中医中药杂志》2023年第10期1237-1240,共4页International Journal of Traditional Chinese Medicine

基　　金：安徽省医学会急诊医学临床研究项目(Ky2018010)。

摘　　要：目的评价八正散加减结合中药熏蒸治疗难治性尿路感染阴虚湿热证患者的临床疗效。方法随机对照试验研究。选取2021年4月-2022年5月本院97例难治性尿路感染阴虚湿热证患者作为观察对象,采用随机数字表法分为观察组49例、对照组48例。对照组予以抗生素治疗,观察组在对照组基础上予以八正散加减+中药熏蒸治疗。2组均治疗14 d。分别于治疗前后进行中医证候评分;采用试管法测定WBC,尿常规亚硝酸盐测定尿细菌计数,记录患者尿常规恢复正常时间、症状缓解时间及症状消失时间;记录不良反应,评价临床疗效。结果观察组总有效率为95.92%(47/49)、对照组为81.25%(39/48),2组比较差异有统计学意义(χ^(2)=5.19,P=0.022)。观察组治疗后中医证候总积分低于对照组(t=13.18,P<0.01),WBC及尿细菌计数低于对照组(t值分别为19.77、22.99,P<0.01)。观察组尿常规恢复正常时间、症状缓解时间及症状消失时间早于对照组(t值分别为23.61、9.80、7.34,P<0.01)。治疗期间,对照组不良反应发生率为8.33%(4/48),观察组未发生不良反应,2组比较差异有统计学意义(χ^(2)=4.26,P=0.039)。结论八正散加减结合中药熏蒸可有效改善难治性尿路感染阴虚湿热证患者的临床症状,提高临床疗效,且未发生不良反应。Objective To evaluate the clinical efficacy of Bazheng Powder combined with Traditional Chinese Medicine(TCM)fumigation in the treatment of refractory urinary tract infection patients with Yin deficiency damp-heat syndrome.Methods Randomized controlled trial design.Ninety-seven patients with Yin deficiency and damp-heat syndrome of refractory urinary tract infection in our hospital from April 2021 to May 2022 were selected as observation objects,and were divided into observation group(49 cases)and control group(48 cases)by random number table method.The control group was treated with antibiotics,and the observation group was treated with Bazheng powder plus or minus plus TCM fumigation on the basis of control group.Both groups were treated for 14 days.TCM syndrome score was performed before and after treatment.Test tube method was used to measure WBC,urine routine nitrite was used to measure urinary bacteria count,and the time to return to normal urine routine,symptom remission time and symptom disappearance time were recorded.Adverse reactions were recorded and clinical efficacy was evaluated.Results The total effective rate was 95.92%(47/49)in the observation group and 81.25%(39/48)in the control group,and the difference between the two groups was statistically significant(χ^(2)=5.19,P=0.022).After treatment,TCM syndrome score of observation group was significantly lower than that of the control group(t=13.18,P<0.01),WBC and urinary bacteria count were significantly lower than those in the control group(t values were 19.77 and 22.99,P<0.01).The time of urine routine recovery,symptom remission and symptom disappearance in the observation group were significantly faster than those in the control group(t values were 23.61,9.80,7.34,P<0.01).During the treatment period,the incidence of adverse reactions was 8.33%(4/48)in the control group,and no adverse reactions occurred in the observation group,the difference between the two groups was statistically significant(χ^(2)=4.26,P=0.039).Conclusion The addition and red

关 键 词：下尿路症状 反复发作尿路感染 阴虚湿热证 八正散 熏洗疗法 

分 类 号：R277.5[医药卫生—中医学]