生殖过程中能量代谢调控与疾病的研究进展  

Research progress in energy metabolism and diseases during reproduction

作　　者：杜琛[1] 李德邦 张倩 陈秀娟[1] Du Chen;Li Debang;Zhang Qian;Chen Xiujuan(Center for Reproductive Medicine,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院生殖医学中心,呼和浩特010050

出　　处：《中华生殖与避孕杂志》2023年第10期1073-1078,共6页Chinese Journal of Reproduction and Contraception

基　　金：内蒙古自治区科技计划项目(2022YFSH0067);内蒙古自治区卫生健康科技计划项目(202202159);内蒙古医科大学面上项目(YKD2022MS017);内蒙古自治区“草原英才”工程青年创新人才项目(2022);内蒙古自治区“十四五”规划课题(NGJGH2022003)。

摘　　要：代谢是贯穿细胞生命周期的重要生理活动,能量底物在生殖过程中具有调节卵泡发育、维持精子运动、影响胚胎植入前发育及诱导母-胎界面免疫耐受等重要功能。正常代谢可促进细胞生长发育,而异常代谢可导致其功能失调,且与女性生殖相关疾病的发生、发展密切相关。本研究对生殖过程中糖代谢、脂代谢和蛋白质(氨基酸)代谢及其与生殖疾病的关系作一概述,有望通过调节能量代谢方式优化卵母细胞体外成熟方案,为胚胎植入母-胎界面能量代谢的研究及不孕不育的诊断和治疗提供新的思路。Metabolism is an important physiological activity throughout the cell life cycle,and energy substrates play an important role in regulating follicle development,maintaining sperm motility,influencing preimplantation embryo development and inducing immune tolerance at the maternal-fetal interface.Normal metabolism can promote cell growth and development,while abnormal metabolism can lead to dysfunction,and is closely related to the occurrence and development of diseases related to female reproduction.This study provides an overview of glucose metabolism,lipid metabolism and protein(amino acid)metabolism in the reproductive process and their relationship with several reproductive diseases.It is expected to optimize in vitro maturation of oocytes by regulating the energy metabolism,and provide new approaches for the study of energy metabolism at the maternal-fetal interface of embryo implantation and the diagnosis and treatment of infertility.

关 键 词：生殖 能量代谢 糖酵解 脂代谢 蛋白质代谢 

分 类 号：R714[医药卫生—妇产科学]