卵泡液中淋巴细胞亚群及其细胞因子对卵子质量的影响  

Effects of lymphocyte subsets and cytokine expression in follicular fluid on oocyte's quality

作　　者：黄金霞 王文娟 Huang Jinxia;Wang Wenjuan(The First Department of Clinical Medicine,Binzhou Medical University,Yantai 264100,China;Reproductive Medicine Center,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medcine,Shanghai 200092,China)

机构地区：[1]滨州医学院第一临床医学院,烟台264100 [2]上海交通大学医学院附属新华医院生殖医学中心,上海200092

出　　处：《中华生殖与避孕杂志》2023年第10期1085-1089,共5页Chinese Journal of Reproduction and Contraception

摘　　要：卵子质量是胚胎发育潜能的决定因素,是影响人类辅助生殖技术结局的主要因素。优质卵子有助于提高受精率、妊娠率和活产率。卵子存在于卵泡液中,卵泡液中的免疫组分参与卵母细胞的生长和排卵,影响卵子质量。CD4+T细胞中的Th1、Th2、Th17细胞和调节性T细胞以及自然杀伤细胞亚群的含量可影响卵子质量,CD8+T细胞可能在卵巢中发挥主动免疫调节的作用,保障卵子的生长。卵泡液中B细胞及其分泌的细胞因子对卵子质量的影响有待进一步研究。本综述主要对卵泡液中T、B淋巴细胞和自然杀伤细胞亚群以及其分泌的白细胞介素(interleukin,IL)-4、IL-10、IL-15、IL-17、肿瘤坏死因子α、γ-干扰素和转化生长因子-β的表达情况进行汇总和分析,探讨卵泡液中淋巴细胞和细胞因子对卵子质量的影响。The quality of oocytes is a key factor in determining the developmental potential of embryo,and is a major factor affecting the outcome of assisted reproductive technology in human.High-quality oocytes contribute to increase fertilization rate,pregnancy rate and live birth rates.Oocytes are present in follicular fluid,the immune components in follicular fluid are involved in the growth and ovulation of oocytes and affect oocyte's growth.The content of Th1,Th2,Th17 cells and regulatory T cells in CD4+T cells and the subsets of natural killer(NK)cells can affect the quality of oocytes.Apart from this,CD8+T cells may play an active immunomodulatory role in the ovary to ensure oocyte's growth.The effects of B cells in follicular fluid and the cytokines they secreted on oocyte's quality need to be further studied.In this review,the expression of T,B lymphocytes and NK cells in follicle fluid and their secretion of interleukin(IL)-4,IL-10,IL-15,IL-17,tumour necrosis factor-α,interferon-gamma and transforming growth factor-βcytokines were summarized and analyzed,and the effects of lymphocytes and cytokines in follicular fluid on oocyte's quality were discussed.

关 键 词：卵泡液 淋巴细胞 白细胞介素 肿瘤坏死因子Α Γ-干扰素 转化生长因子-Β 

分 类 号：R714.8[医药卫生—妇产科学]