胰岛素样生长因子1在母-胎界面生物学功能和调节机制进展  

Biological functions and regulatory mechanisms of insulin-like growth factor 1 at the maternal-fetal interface

作　　者：王琳琳[1] 沈燕琼 杨静 武娅娅 李龙飞 程艳香[1] Wang Linlin;Shen Yanqiong;Yang Jing;Wu Yaya;Li Longfei;Cheng Yanxiang(Department of Obstetrics and Gynecology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation Shenzhen Zhongshan Institute for Reproduction and Genetics Reproductive Medicine Clinical Research Center,Shenzhen Zhongshan Urology Hospital,Shenzhen 518045,China)

机构地区：[1]武汉大学人民医院妇产科,武汉430060 [2]深圳市围着床期生殖免疫重点实验室,深圳中山生殖与遗传研究所,深圳中山泌尿外科医院生殖医学临床研究中心,深圳518045

出　　处：《中华生殖与避孕杂志》2023年第10期1090-1097,共8页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金项目面上项目(82071655);广东省自然科学基金(2019A1515011315,2022A1515010850);深圳市自然科学基金(JCYJ20190813161010761,JCYJ20210324123601004)。

摘　　要：在母-胎界面,胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)不仅可通过调控滋养细胞对氨基酸、葡萄糖、脂肪酸等的吸收转运,促进胎儿的生长发育,还可以通过调控蜕膜代谢、免疫应答、炎症等过程,进而调控蜕膜细胞的增殖分化,血管新生及蜕膜化过程,但目前母体蜕膜方面的研究还非常有限。IGF-1受到上游激素、细胞因子、小分子营养物质、氧气、环境污染物等的调控。生长激素、米非司酮、泼尼松龙、褪黑素等药物调控IGF-1的表达,进而改善妊娠结局。对IGF-1在母-胎界面的作用机制及上游调控机制进行解析,有望发现更多改善妊娠结局的潜在靶点,为临床妊娠相关疾病带来新的诊疗策略。At the maternal-fetal interface,insulin-like growth factor 1(IGF-1)promotes fetal growth by regulating transport and absorption of amino acid,glucose,and fatty acid in trophoblast cells.Additionally,IGF-1 facilitates proliferation and differentiation of decidual cells,angiogenesis,and decidualization via regulating metabolism,immune responses,and anti-or pro-inflammatory responses of decidual cells.However,more studies are needed to verify the underlying mechanisms of IGF-1 in maternal decidual cells.IGF-1 is regulated by upstream hormones,cytokines,small molecule nutrients,oxygen,and environmental pollutants.Drugs,such as growth hormone,mifepristone,prednisolone and melatonin,can regulate the expression of IGF-1 and further improve pregnancy outcomes.Verifying the upstream and downstream mechanisms of IGF-1 at the maternal-fetal interface helps to find out more potential targets for the diagnosis and treatment of pregnancy-related diseases,and provide new ideas for the field.

关 键 词：胰岛素生长因子1 代谢 环境污染物 激素 蜕膜化 

分 类 号：R714[医药卫生—妇产科学]