白消安诱导造血干细胞损伤动物模型的建立及应用  

Establishment and Application of Animal Model of Hematopoietic Stem Cell Injury Induced by Busulfan

作　　者：孙宇航 管博文 孟爱民 SUN Yuhang;GUAN Bowen;MENG Aimin(Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences/Comparative Medicine Center,Peking Union Medical College/NHC Key Laboratory of Human Disease Comparative Medicine/Beijing Engineering Research Center for Laboratory Animal Models of Major Human Diseases/National Human Diseases Animal Mode Resource Center,Beijing 100021,China)

机构地区：[1]中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病比较医学重点实验室,北京市人类重大疾病实验动物模型工程技术研究中心,国家人类疾病动物模型资源库,北京100021

出　　处：《医学综述》2022年第23期4649-4654,共6页Medical Recapitulate

基　　金：国家自然科学基金(81972975);国家重点研发计划(2017YFA0105204)。

摘　　要：白消安临床使用时一直存在治疗窗较窄,用药后个体敏感性差异大,易发生血药浓度不足导致的移植失败或浓度过高导致的中毒反应等严重问题。白消安构建的造血干细胞损伤动物模型多用于优化临床治疗方案和造血干细胞损伤机制研究,此类模型对寻找有预测作用的生物标志物、探索个性化化疗方案、提高临床治疗及预处理效果、阐明造血干细胞损伤机制具有重要意义。完善白消安诱导的造血干细胞损伤动物模型将为多种疾病机制研究和临床用药指导研究等提供帮助。Clinical application of busulfan has serious problems of narrow therapeutic window,great differences in individual sensitivity,prone to transplant failure due to insufficient blood drug concentration or toxic reaction due to high concentration.The animal models of hematopoietic stem cell injury constructed by bulsulfan are mostly used to optimize the clinical treatment scheme and study the mechanism of hematopoietic stem cell injury.Such models are of great significance for finding biomarkers with predictive effects,exploring individualized chemotherapy schemes,improving the clinical treatment and pretreatment effects,and clarifying the mechanism of hematopoietic stem cell injury.Improving the animal model of hematopoietic stem cell injury induced by busulfan will provide help for the study of various disease mechanisms and clinical medication guidance.

关 键 词：白消安 造血干细胞 动物模型 造血损伤 

分 类 号：R332[医药卫生—人体生理学]