晚期糖基化终末产物诱导炎症与良性前列腺增生的研究进展  

Research Progress of Advanced Glycation End Product Induced Inflammation and Benign Prostatic Hyperplasia

作　　者：陈官恒 冯磊光[2] CHEN Guanheng;FENG Leiguang(Harbin Medical University,Harbin 150081,China;Department of Clinical Laboratory,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学,哈尔滨150081 [2]哈尔滨医科大学附属第一医院检验科,哈尔滨150001

出　　处：《医学综述》2022年第23期4660-4665,共6页Medical Recapitulate

基　　金：国家重点研发计划(2021YFC2009306,2021YFC2009300)。

摘　　要：良性前列腺增生(BPH)是中老年男性的一种慢性进行性疾病,严重影响中老年男性的生活质量。晚期糖基化终末产物(AGE)是通过非酶促反应形成的结构多样的不可逆聚合物,具有细胞毒性作用。AGE可通过非受体途径(包括修饰脂质、促进细胞衰老和使肠道菌群发生改变)或受体途径诱导炎症。炎症在BPH中扮演重要角色,即炎症可诱发或加重BPH的发生发展,抑制AGE的药物可以缓解BPH的症状。因此,检测AGE在血液中的浓度、进一步明确AGE诱导炎症的作用机制以及阻断其激活的炎症通路对BPH的预防、诊断以及治疗具有重要意义。Benign prostatic hyperplasia(BPH)is a chronic progressive disease in middle-aged and elderly men,which seriously affects their quality of life.Advanced glycation end products(AGE)are structurally diverse irreversible polymers formed by non-enzymatic reactions and have cytotoxic effects.AGE can induce inflammation through non-receptor pathways(including modifying lipids,promoting cell senescence,and altering intestinal flora)or receptor pathways.Inflammation plays a very important role in BPH,that is,inflammation can induce or aggravate the occurrence and development of BPH.Drugs that inhibit AGE can relieve the symptoms of BPH.Therefore,it is of great significance to detect the concentration of AGE in the blood,further clarify the mechanism of AGE-induced inflammation and block the activation of inflammatory pathways for the diagnosis,prevention and treatment of BPH.

关 键 词：良性前列腺增生 晚期糖基化终末产物 炎症 糖尿病 

分 类 号：R697.3[医药卫生—泌尿科学]