尖锐湿疣患者皮损TLR9/MyD88/IRF7信号通路及其与血清炎性指标的相关性  

TLR9/MyD88/IRF7signaling pathway in skin lesions of patients with condyloma acuminatum and its correlation with serum inflammatory indexes

作　　者：王瑶[1] 李涛 刘秀[1] 郭秋虹 张沛 WANG Yao;LI Tao;LIU Xiu;GUO Qiu-hong;ZHANG Pei(Sichuan Provincial People′s Hospital,Chengdu,Sichuan 610072,China)

机构地区：[1]四川省人民医院门诊部,四川成都610072

出　　处：《中华医院感染学杂志》2023年第20期3122-3126,共5页Chinese Journal of Nosocomiology

基　　金：四川省医学会基金资助项目{川学会医字[2022]93号}。

摘　　要：目的探讨尖锐湿疣患者皮损Toll样受体9(TLR9)/髓样分化因子88(MyD88)/干扰素调节因子7(IRF7)信号通路及其与血清炎性指标的相关性。方法回顾性收集2020年2月-2022年10月四川省人民医院收治的122例尖锐湿疣患者临床资料作为尖锐湿疣组,选取同期于四川省人民医院进行体检的135例皮肤健康体检者体检资料作为健康对照组,统计两组一般资料,比较两组疣体组织TLR9/MyD88/IRF7信号通路指标及血清炎性指标,根据患者感染人乳头瘤病毒亚型种类将其分为单一感染组(68例)和多重感染组(54例),比较两组疣体组织TLR9/MyD88/IRF7信号通路指标及血清炎性指标,采用Pearson相关系数分析尖锐湿疣患者TLR9/MyD88/IRF7信号通路指标与血清炎性指标的相关性。结果尖锐湿疣组疣体组织中TLR9信使核糖核酸(mRNA)、MyD88 mRNA、IRF7 mRNA水平高于健康对照组(P<0.05);尖锐湿疣组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)高于健康对照组,血清IL-17低于健康对照组(P<0.05);多重感染组疣体组织中TLR9 mRNA、MyD88 mRNA、IRF7 mRNA水平及TNF-α、IL-6、hs-CRP高于单一感染组,IL-17低于单一感染组(P<0.05);尖锐湿疣患者疣体组织中TLR9 mRNA、MyD88 mRNA、IRF7 mRNA与患者血清TNF-α、IL-6、hs-CRP呈正相关,与血清IL-17呈负相关(P<0.05)。结论尖锐湿疣组患者机体TLR9/MyD88/IRF7信号通路相关指标及炎性指标较对照组变化明显,TLR9/MyD88/IRF7信号通路相关指标表达水平与炎性指标明显相关。OBJECTIVE To investigate the changes in Toll like receptor 9(TLR9)/myeloid differentiation factor 88(MyD88)/interferon regulatory factor 7(IRF7)signaling pathway in skin lesions of patients with condyloma acuminatum and its correlation with serum inflammatory indexes.METHODS Clinical data of 122patients with condyloma acuminatum treated in Sichuan Provincial People′s Hospital from Feb.2020to Oct.2022were retrospectively collected as the condyloma acuminatum group,and physical examination data of 135patients with healthy skin who underwent physical examination in Sichuan Provincial People′s Hospital during the same period were selected as the healthy control group.General data of the two groups were analyzed.The TLR9/MyD88/IRF7signaling pathway indexes and serum inflammatory indexes were compared between the two groups.According to the types of human papillomavirus subtypes,the patients were divided into a single infection group(68cases)and amultiple infection group(54cases).The TLR9/MyD88/IRF7signaling pathway indexes and serum inflammatoryindexes were compared between the two groups.Pearson correlation coefficient was used to analyze the correlationbetween TLR9/MyD88/IRF7signaling pathway indexes and serum inflammatory indexes in patients with condyloma acuminatum.RESULTS The expression levels of TLR9messenger ribonucleic acid(mRNA),MyD88mRNAand IRF7mRNA in wart tissues of condyloma acuminatum group were higher than those in skin tissues of healthycontrol group(P<0.05).The serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and hypersensitive C-reactive protein(hs-CRP)in condyloma acuminatum group were higher than those in healthy controlgroup,while the level of serum IL-17of the condyloma acuminatum group was lower than that of the healthy control group(P<0.05).The expression levels of TLR9mRNA,MyD88mRNA,IRF7mRNA and serum TNF-α,IL-6,hs-CRP in the multiple infection group were higher than those in the single infection group,while the levelof serum IL-17was lower than that in the single infe

关 键 词：尖锐湿疣 感染 TOLL样受体9 髓样分化因子88 干扰素调节因子7 信号通路 炎性指标 相关性 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]