长链非编码RNA与动脉粥样硬化病变中血管内皮功能失调关系的研究进展  

Research Progress of Long Non-coding RNA and Vascular Endothelial Dysfunction in Atherosclerotic Lesions

作　　者：金丽霞 刘丹[2] 张广炜[2] 冯佳佳 JIN Lixia;LIU Dan;ZHANG Guangwei;FENG Jiajia(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,China;Department of Neurology,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,China)

机构地区：[1]内蒙古科技大学包头医学院,内蒙古包头014010 [2]内蒙古科技大学包头医学院第一附属医院神经内科,内蒙古包头014010

出　　处：《医学综述》2022年第16期3146-3150,共5页Medical Recapitulate

基　　金：内蒙古自治区人才开发基金项目(内人社办函〔2019〕114号)。

摘　　要：动脉粥样硬化主要发生在全身大、中动脉段,颈动脉粥样硬化往往可以引起脑梗死等急性重症疾病。血管内皮细胞是动脉内膜的主要组成部分,内皮细胞功能障碍是动脉粥样硬化形成的起始环节。近年来长链非编码RNA(lncRNA)成为各医学领域的研究热点,在动脉粥样硬化病变血管内皮功能失调研究中起重要的调控作用。未来,深入研究lncRNA与动脉粥样硬化病变中血管内皮功能失调的调控机制,将为动脉粥样硬化相关疾病的诊断和治疗提供新思路。Atherosclerosis mainly occurs in the large and middle arteries of the whole body.Carotid atherosclerosis has attracted much attention because it can often cause acute and severe diseases such as cerebral infarction.Endothelial cells are the main component of the intima of arteries,and endothelial dysfunction is the beginning of atherosclerosis.In recent years,long non-coding RNA(lncRNA)has become a research hotspot in various fields of medicine,which plays an important regulatory role in the vascular endothelial dysfunction in atherosclerotic lesions.In the future,in-depth study on the regulatory mechanism of lncRNA and vascular endothelial dysfunction related diseases in atherosclerotic lesions will provide new ideas for the diagnosis and treatment of atherosclerotic diseases.

关 键 词：动脉粥样硬化 长链非编码RNA 血管内皮功能失调 

分 类 号：R543.5[医药卫生—心血管疾病]