脂肪酸在糖尿病周围神经病变发病机制中的作用研究进展  

Research Progress in Role of Fatty Acids in Pathogenesis of Diabetic Peripheral Neuropathy

作　　者：连晓阳 原萌谦 李晓洁 陈栋[1] 刘成勇[1] 吴晓亮[1] 徐斌[3] 钟京琛 LIAN Xiaoyang;YUAN Mengqian;LI Xiaojie;CHEN Dong;LIU Chengyong;WU Xiaoliang;XU Bin;ZHONG Jingchen(Department of Acupuncture and Rehabilitation,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China;Jiangsu Health Vocational College,Nanjing 210029,China;Key Laboratory of Acupuncture and Drug Combination of Ministry of Education,Nanjing University of Traditional Chinese Medicine,Nanjing 210004,China)

机构地区：[1]江苏省中医院针灸康复科,南京210029 [2]江苏卫生健康职业学院,南京210029 [3]南京中医药大学针药结合教育部重点实验室,南京210004

出　　处：《医学综述》2023年第8期1618-1622,共5页Medical Recapitulate

基　　金：国家自然科学基金(81873238)。

摘　　要：糖尿病周围神经病变(DPN)是1型和2型糖尿病最常见的慢性并发症,糖尿病患者的内分泌功能紊乱可导致机体代谢异常,脂质代谢与DPN发病机制密切相关,其代谢产物对神经功能具有不同的调节作用。脂肪酸作为脂质代谢中的重要底物,参与构成细胞膜、维持细胞膜正常功能并与周围神经系统中髓鞘的形成相关。因此,脂肪酸紊乱可能与DPN的发生发展密切相关,但学术界尚未对其给予充分关注。深入研究脂肪酸紊乱所致的脂代谢异常与DPN发生发展的相关性,可能为DPN的治疗提供新思路。Diabetes peripheral neuropathy(DPN)is the most common chronic complication of type 1 and type 2 diabetes.The disordered endocrine state of diabetic patients can cause many metabolic abnormalities.Lipid metabolism is closely related to the pathogenesis of DPN,and its metabolites have different regulatory functions on neural function.As an important substrate in lipid metabolism,fatty acids participate in the formation of cell membrane,maintain the normal function of cell membrane and are related to the formation of myelin sheath in the peripheral nervous system.Therefore,fatty acid disorder may be closely related to the occurrence and development of DPN,but the academic community has not paid enough attention to it.Further study on the correlation between abnormal lipid metabolism caused by fatty acid disorders and the occurrence and development of DPN may provide new ideas for the treatment of DPN.

关 键 词：糖尿病周围神经病变 脂肪酸 脂质代谢 胰岛素抵抗 线粒体 

分 类 号：R589.2[医药卫生—内分泌]