盆腔器官脱垂发生发展相关危险因素及机制研究进展  

Research Progress in Risk Factors and Mechanisms Related to Occurrence and Development of Pelvic Organ Prolapse

作　　者：肖雅 洪莉[1] 李素廷 陈茂 黄筱雨 朱芳谊 XIAO Ya;HONG Li;LI Suting;CHEN Mao;HUANG Xiaoyu;ZHU Fangyi(Department of Gynecology and Obstetrics,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院妇产科,武汉430060

出　　处：《医学综述》2023年第4期706-710,共5页Medical Recapitulate

基　　金：国家重点研发计划(2018YFC2002204);国家自然科学基金面上项目(81971364);中华预防医学会中国妇女盆底功能障碍防治专项项目(201817092)。

摘　　要：盆腔器官脱垂(POP)是由于盆底支撑组织薄弱和功能缺陷而导致阴道内盆腔器官下降的多因素疾病,是临床常见的盆底功能障碍性疾病,多见于中老年人。POP会影响排尿、排便和性功能,部分患者因宫颈及阴道暴露而易引发尿路感染,患者生活质量严重降低。POP的发病机制复杂,受到环境因素和遗传因素等的影响。POP的主要危险因素为妊娠、阴道分娩,其他危险因素还包括衰老、肥胖、遗传因素等。随着研究的不断深入,POP发生发展相关危险因素及其机制将会逐渐清晰。Pelvic organ prolapse(POP)is a multi-factor disease that leads to the decline of pelvic organs in the vagina due to weak supporting tissue and functional defects of the pelvic floor,which is a common pelvic floor dysfunction disease in clinic,and is more common in the middle-aged and elderly.POP will affect micturition,defecation and sexual function,and some patients are prone to urinary tract infection due to cervical and vaginal exposure,seriously reducing the quality of life of the patients.The pathogenesis of POP is complex,which is affected by environmental factors and genetic factors.The main risk factors of POP are pregnancy and vaginal delivery,and other risk factors include aging,obesity,genetic factors and so on.With the deepening of the research,the risk factors related to the occurrence and development of POP and its mechanism will gradually become clear.

关 键 词：盆腔器官脱垂 盆底肌肉 危险因素 致病机制 

分 类 号：R711.23[医药卫生—妇产科学]