醋酸甲羟孕酮在子宫内膜癌手术治疗患者辅助干预中的应用  

The Use of Medroxyprogesterone Acetate in Adjuvant Interventions for Patients Undergoing Surgical Treatment for Endometrial Cancer

作　　者：薛文玲 尹保娜 Xue Wenling;Yin Baona(Department of Gynecology and Oncology,Jiaozuo Maternal and Child Health Hospital,Jiaozuo,Henan,454000,China)

机构地区：[1]焦作市妇幼保健院妇瘤科,河南焦作454000

出　　处：《黑龙江医学》2023年第22期2720-2723,共4页Heilongjiang Medical Journal

基　　金：河南省医学科技攻关项目(2019002613)。

摘　　要：目的:探析醋酸甲羟孕酮辅助子宫内膜癌手术的效果及对患者血清指标、生活质量的影响。方法:选取2020年1月—2022年2月焦作市妇幼保健院接受手术治疗的80例子宫内膜癌患者为研究对象,采用抽签法分为对照组(n=40,单独微创手术治疗)和观察组(n=40,醋酸甲羟孕酮配合手术治疗)。比较两组的术后病理情况、血清指标(激素水平和肿瘤标志物)、术后生活质量及并发症发生情况。结果:治疗后,观察组患者肿瘤病灶改善情况高于对照组,差异有统计学意义(χ^(2)=5.128,P<0.05);观察组患者卵泡激素(FSH)、促黄体生成素(LH)、雌二醇(E2)均低于对照组,差异具有统计学意义(t=7.622、6.148、10.919,P<0.05);观察组患者糖类抗原(CA)125、CA19-9、CA153、人附睾蛋白4(HE4)、癌胚抗原(CEA)水平均低于对照组,差异有统计学意义(t=6.361、5.683、7.708、5.131、29.828,P<0.05);观察组患者生活质量综合评定问卷(GOQLI-74)各维度评分均高于对照组,差异有统计学意义(t=7.494、4.317、5.080、6.214,P<0.05);观察组患者不良事件发生率高于对照组,差异无统计学意义(χ^(2)=1.143,P>0.05)。结论:采用醋酸甲羟孕酮辅助子宫内膜癌患者的手术治疗可促进病情改善,对降低患者雌激素水平及肿瘤标志物水平并提升术后生活质量均有积极意义,且术中联合应用此药并未明显增加术后不良事件发生风险,安全性尚可。Objective:To explore the effect of medroxyprogesterone acetate as an adjunct to endometrial cancer surgery and its impact on patients’serum indicators and quality of life.Methods:80 patients with endometrial cancer who underwent surgical treatment in the hospital from January 2020 to February 2022 were selected for the study and were divided into a control group(n=40,minimally invasive surgical treatment alone)and an observation group(n=40,medroxyprogesterone acetate with surgical treatment)using a lottery method.Postoperative pathology,serum indices(hormone levels and tumor markers),postoperative quality of life and complications were compared between the two groups.Results:After treatment,the improvement of tumor lesions in the observation group was higher than that in the control group,and the difference was statistically significant(χ^(2)=5.128,P<0.05).Follicle hormone(FSH),luteinizing hormone(LH)and estradiol(E2)were lower in the observation group than in the control group,and the differences were statistically significant(t=7.622,6.148,10.919,P<0.05).The levels of glycoantigen(CA)125,CA19-9,CA153,human epithelial protein 4(HE4),and carcinoembryonic antigen(CEA)were lower in the observation group than in the control group,and the differences were statistically significant(t=6.361,5.683,7.708,5.131,29.828,P<0.05).The GOQLI-74 scores of all dimensions were higher in the observation group than in the control group,and the differences were statistically significant(t=7.494,4.317,5.080,6.214,P<0.05).The incidence of adverse events was higher in the observation group than in the control group,and the difference was not statistically significant(χ^(2)=1.143,P>0.05).Conclusion:The use of medroxyprogesterone acetate as an adjunct to surgical treatment of endometrial cancer patients can promote improvement of the disease,and has positive significance in reducing estrogen levels and tumor marker levels and improving postoperative quality of life.

关 键 词：子宫内膜癌 醋酸甲羟孕酮 手术辅助 血清肿瘤标志物 生活质量 

分 类 号：R713[医药卫生—妇产科学]