氧化铁纳米颗粒的体内药动学影响因素  

In Vivo Pharmacokinetic Influence Factors of Iron Oxide Nanoparticles

作　　者：唐昊楠 刘丽娟[1] 金观桥[1] TANG Haonan;LIU Lijuan;JIN Guanqiao(Medical Imaging Center,Guangxi Medical University Cancer Hospital,Nanning 530021,China)

机构地区：[1]广西医科大学附属肿瘤医院医学影像中心,南宁530021

出　　处：《医学综述》2023年第19期3765-3769,共5页Medical Recapitulate

基　　金：广西影像医学临床医学研究中心建设项目(桂科AD20238096);广西壮族自治区卫生健康委员会重点(培育)实验室建设项目(ZPZH2020004);北京医学奖励基金会课题研究项目(YXJL-2022-0665-0210)。

摘　　要：随着纳米材料的不断发展,氧化铁纳米颗粒(IONPs)已广泛应用于医学研究领域。IONPs的大小、形状、表面修饰及电荷等不同性质均会对其在体内的吸收、分布、代谢、排泄等过程产生一定影响。改变影响IONPs的药动学因素,有助于制备体内循环时间长、靶向性高且毒性低的纳米颗粒,可用于药物在体内的靶向传递和肿瘤治疗,实现肿瘤的诊疗一体化。未来深入研究IONPs的体内药动学影响因素,可以为疾病的治疗提供新思路。With the continuous development of nanomaterials,iron oxide nanoparticles(IONPs)have found extensive applications in medical research.The size,shape,surface modification and charge of IONPs all play a role in their absorption,distribution,metabolism and excretion processes within the body.By manipulating the pharmacokinetic factors that influence IONPs,it is possible to design nanoparticles with prolonged circulation time,enhanced targeting capability,and reduced toxicity,thus facilitating targeted drug delivery for integrated tumor diagnosis and treatment.Further investigation into the pharmacokinetic factors that affect IONPs in vivo holds promise for offering novel perspectives on disease treatment in the future.

关 键 词：氧化铁纳米颗粒 药动学 粒径 形状 表面修饰 

分 类 号：R318.08[医药卫生—生物医学工程] R969.1[医药卫生—基础医学]