基于脑-肠轴理论探讨针灸的起效机制  

Discussion on Mechanism of Acupuncture and Moxibustion Based on Brain-gut Axis Theory

作　　者：鲁菁 邵玉莹 冯楚文 屈媛媛 郭述豪 陈涛 李彬彬 杨添淞[2,3] LU Jing;SHAO Yuying;FENG Chuwen;QU Yuanyuan;GUO Shuhao;CHEN Tao;LI Binbin;YANG Tiansong(Graduate School of Heilongjiang University of Chinese Medicine,Harbin 150040,China;DepartmentⅡof Rehabilitation,the First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang Key Laboratory of Traditional Chinese Medicine Informatics,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学研究生学院,哈尔滨150040 [2]黑龙江中医药大学附属第一医院康复二科,哈尔滨150040 [3]黑龙江省中医药信息学重点实验室,哈尔滨150040

出　　处：《医学综述》2023年第19期3867-3872,共6页Medical Recapitulate

基　　金：国家自然科学基金(82074539);黑龙江省“春晖计划”合作科研项目(202201357);黑龙江省自然科学基金(YQ2023H019,LH2020H092);黑龙江省中医药科研项目(ZHY2022-136);黑龙江省中医药学会青年人才托举工程项目(2022-QNRC1-05)。

摘　　要：脑-肠轴以肠道微生物为关键介质,通过动态调节大脑与肠道信息交流网络平衡,参与介导神经内分泌系统、免疫系统、消化系统等的生理及病理变化。针灸作为传统外治法,已被证实具有良性调节神经内分泌系统、炎症反应及肠道菌群等作用,为针灸通过调节脑-肠轴防治疾病提供客观证据支持,但其对脑-肠轴的调控途径仍有待进一步明晰。因此,以经络循行为指导系统梳理针灸对脑-肠轴的调控效应,以期基于脑-肠轴为针灸效应机制研究提供新视角。Brain-gut axis takes gut microorganisms as the key medium,and participates in mediating physiological and pathological changes of neuroendocrine,immunity,digestion and other systems by dynamically adjusting the balance of information exchange network between brain and gut.As a traditional external therapy,acupuncture and moxibustion has been proved to have the function of benign regulation of neuroendocrine network,inflammatory reaction and intestinal flora,which provides objective evidence support for acupuncture and moxibustion to prevent and treat diseases by regulating brain-gut axis,but its regulation approach to brain-gut axis remains to be further clarified.Therefore,the regulation effect of acupuncture and moxibustion on brain-gut axis was systematically analyzed under the guidance of meridian circulation theory,in order to provide a new perspective for the study of acupuncture effect mechanism.

关 键 词：针灸 脑-肠轴 起效机制 

分 类 号：R245[医药卫生—针灸推拿学]