基于胆固醇逆转运途径探讨中药抗动脉粥样硬化的研究进展  

Research Progress of Chinese Medicine against Atherosclerosis Based on Cholesterol Reverse Transport Pathway

作　　者：朴丽兵 赵彦蓉 魏丽萍[2] PIAO Libing;ZHAO Yanrong;WEI Liping(Graduate School of Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Department of Cardiology,Tianjin People′s Hospital,Tianjin 300121,China)

机构地区：[1]天津中医药大学研究生院,天津301617 [2]天津市人民医院心内科,天津300121

出　　处：《医学综述》2023年第19期3884-3889,共6页Medical Recapitulate

基　　金：京津冀基础研究合作专项(19JCZDJC63900)。

摘　　要：脂质代谢紊乱是导致动脉粥样硬化(As)的主要原因,尽管已有相关中药被证实具有降脂作用,但其确切发病机制仍在进一步探索中。胆固醇逆转运(RCT)是机体调节As胆固醇外排的重要机制。中医认为,As的病因为元气不充、阳气亏虚最终导致脉道失运,主张采用“益气、活血、解毒、化痰”等治疗原则,通过中药发挥调节血脂、改善体内循环以及抗炎等作用。近年来,有关中药单体及复方基于RCT途径抗As的临床研究已有初步成效。因此,对中药抗As的相关机制进行深入探讨,可为中药靶向治疗心血管疾病提供理论依据。Lipid metabolism disorders is the main cause of atherosclerosis(As).Although related traditional Chinese medicines(TCM)have been confirmed to have lipid-lowering effects,the exact pathogenesis is still being further explored.Reverse cholesterol transport(RCT)is an important mechanism for the body to regulate cholesterol efflux in atherosclerosis.The TCM believes that the cause of As can be attributed to the lack of vitality and the insufficiency of yang qi leading to the insufficiency of the channel transportation,and advocates the treatment principle of"replenishing qi,promoting blood circulation,detoxifying,and resolving phlegm",by which the Chinese medicine plays the role of regulating blood lipids,improving circulation and anti-inflammation.In recent years,there have been preliminary results in clinical research on the anti-As of Chinese medicine monomers and compounds through the RCT pathway.Therefore,through the in-depth discussion of the related mechanism of TCM against As,a theoretical basis for the TCM targeted treatment of cardiovascular diseases can be provided.

关 键 词：动脉粥样硬化 胆固醇逆转运 中药单体 中药复方 心脑血管疾病 

分 类 号：R541.4[医药卫生—心血管疾病]