儿童造血干细胞移植后皮肤GVHD评估与预防最佳证据总结  

Summary of best evidence for assessment and prevention of cutaneous graft-versus-host disease after hematopoietic stem cell transplantation in children

作　　者：杨利灵 詹莎 陈凯[1] 陆群峰[2] 顾莺 吴萌 王怡怡 薛晓燕 Yang Liling;Zhan Sha;Chen Kai;Lu Qunfeng;Gu Ying;Wu Meng;Wang Yiyi;Xue Xiaoyan(Department of Hematology and Oncology,Shanghai Children′s Hospital,Shanghai 200062,China)

机构地区：[1]上海市儿童医院血液肿瘤科,上海200062 [2]上海市儿童医院护理部,上海200062 [3]复旦大学附属儿科医院护理部

出　　处：《护理学杂志》2023年第20期39-44,共6页Journal of Nursing Science

基　　金：上海申康医院发展中心重大临床研究项目(SHDC2020CR4089);复旦大学循证护理中心证据转化与临床应用(Fudanebn202226);上海交通大学医学院护理科研重点项目(Jyhz2324)。

摘　　要：目的 总结儿童造血干细胞移植后皮肤移植物抗宿主病护理最佳证据,为临床护理提供指引。方法 计算机检索BMJ Best Practice、UpToDate、JBI循证卫生保健中心数据库、中国抗癌协会护理专业委员会、PubMed、中国知网、万方数据等数据库,检索时限为2000年1月1日至2023年5月31日。结果 共纳入文献17篇(临床决策3篇,指南7篇,系统评价1篇,专家共识4篇,证据总结2篇),总结出皮肤评估、皮肤防护、皮肤不良反应的处理、用药指导、随访与筛查5个方面24条最佳证据。结论 总结的儿童造血干细胞移植后皮肤移植物抗宿主病护理最佳证据,可作为指引用于临床护理。Objective To summarize the best evidence for care of cutaneous graft-versus-host disease(GVHD)after hematopoietic stem cell transplantation in children,and to provide guidance for clinical care.Methods BMJ Best Practice,UpToDate,the Joanna Briggs Institute Evidence-Based Practice Database,Nursing Professional Committee of Chinese Anti-Cancer Association,PubMed,CNKI,WanFang data and other databases were searched from January 1,2000 to May 31,2023.Results A total of 17 publications were eligible(3 clinical decision recommendations statements,7 guidelines,1 systematic review,4 expert consensus reports and 2 evidence summaries),and 24 pieces of best evidence were summarized in 5 aspects:skin assessment,skin protection,management of adverse skin reactions,medication guidance,follow-up and screening.Conclusion The best evidence for the care of cutaneous GVHD after hematopoietic stem cell transplantation in children can be used as a guidance for clinical care.

关 键 词：儿童 造血干细胞移植 移植物抗宿主病 皮肤 用药指导 证据总结 循证护理 

分 类 号：R473.72[医药卫生—护理学]