水性光引发剂研究进展及其在生物医学中的应用  

Water-soluble Photoinitiators:State of Art and Applications in Biomedical Science

作　　者：孙逊 罗鹏 王涛 袁斌斌 庞玉莲[1,2] 邹应全 SUN Xun;LUO Peng;WANG Tao;YUAN Binbin;PANG Yulian;ZOU Yingquan(College of Chemistry,Beijing Normal University,Beijing 100875,P.R.China;Hubei Gurun Technology Co.,Ltd.,Jingmen 448000,Hubei,P.R.China)

机构地区：[1]北京师范大学化学学院,北京100875 [2]湖北固润科技股份有限公司,湖北荆门448000

出　　处：《影像科学与光化学》2023年第5期197-229,共33页Imaging Science and Photochemistry

摘　　要：近年来,水性光固化技术被越来越多地应用于生物医学领域,如牙科材料、3D生物打印、体外聚合、细胞封装等。水溶性好、细胞毒性低、引发效率高的水性光引发剂是光固化技术在生物医学领域广泛发展应用的关键物质。为此,研究人员做了大量的工作,设计开发了一系列性能优良的水性光引发剂,并研究了其在药物控释、生物仿生解毒器、细胞传感器、软骨修复、断层扫描体积生物打印、生物组织粘合剂、光动力肿瘤治疗等方面的应用效果。本文概述了水性光引发剂的种类、作用机制以及在生物医学中的一些应用研究,并对水性光引发剂的发展方向进行了展望,希望能为水性光引发剂的发展以及应用带来一些启发。In recent years,waterborne photo-curable technology have been used in biomedical applications,such as dental materials,3D biological printing,in vitro polymerization,cell encapsulation,etc.Water-soluble photoinitiators exhibiting good water solubility,low cytotoxicity,and high initiation efficiency have become key substances for the widespread development and application of photo-curable technology in biomedical applications.Therefore,researchers designed and synthesized a serious of water-soluble photoinitiators,and explored the application of this photoinitiators in drug delivery,bio-inspired detoxification,cell sensor,cartilage repair,volumetric bioprinting,biological tissue adhesive and photodynamic tumor therapy,and so on.In this review,the recent state of art of water-soluble photoinitiator including types,photoinitiation mechanisms,and application examples in biomedicine of water-based photoinitiators is provided.Moreover,the perspective on the future development of water-soluble photoinitiators is also discussed,hoping to provide some inspiration for the development and application of water-based photoinitiating systems.

关 键 词：水性光引发剂 Ⅰ型水性光引发剂 Ⅱ水性型光引发剂 双光子水性光引发剂 生物医学应用 

分 类 号：R318[医药卫生—生物医学工程] TQ421.7[医药卫生—基础医学]