联合低频振幅和度中心性的高度近视患者脑功能研究  

A Brain Function Study of Combining Amplitude of Low Frequency Fluctuations and Degree Centrality in Patients with High Myopia

作　　者：张晓盼 杨帆[2] 金学民[2] 程敬亮[1] 文宝红[1] ZHANG Xiaopan;YANG Fan;JIN Xuemin;CHENG Jingliang;WEN Baohong(Department of Magnetic Resonance Imaging,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,P.R.China;Department of Ophthalmology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,P.R.China)

机构地区：[1]郑州大学第一附属医院磁共振科,河南郑州450052 [2]郑州大学第一附属医院眼科,河南郑州450052

出　　处：《影像科学与光化学》2023年第5期230-237,共8页Imaging Science and Photochemistry

基　　金：河南省重点研发与推广专项(科技攻关)(222102310317,232102310094);郑州大学第一附属医院院内青年创新基金项目(YNQN2017160)资助。

摘　　要：探讨联合低频振幅(ALFF)和度中心性(DC)方法在高度近视(HM)患者静息状态下局部大脑的功能变化。选取45例患者作为HM组,选择与之匹配的46例双眼正常视力参与者作为对照组。所有被试进行静息态功能磁共振成像扫描。ALFF和DC的方法进行局部脑功能差异的分析。组间比较采用基于体素层面的独立样本t检验。结果显示与对照组相比,HM组在左眶部额下回、右距状裂周围皮层、右前扣带与旁扣带脑回、左丘脑、左顶下缘角回、右顶下缘角回和左中央旁小叶的ALFF值存在统计学差异(P<0.05);HM组在右颞下回、左颞下回、右前扣带与旁扣带脑回、左眶内额上回、左距状裂周围皮层、右梭状回、左顶下缘角回和左中央旁小叶的DC值存在统计学差异(P<0.05)。联合低频振幅和度中心性在HM患者大脑神经元活动及脑功能网络改变判断中具有较高的应用价值。To explore the abnormal changes of local brain function in patients with high myopia(HM)during the resting state by a combining amplitude of low frequency fluctuations(ALFF)and degree centrality(DC)method.A total of 45 HM patients were selected as the HM group,and 46 subjects with normal binocular vision were selected as the control group.All subjects underwent a resting-state functional magnetic resonance imaging scan.Altered local brain function was analyzed by using combined ALFF and DC.Comparison between groups was performed by two-sample t test based on voxel level.The results showed that compared with the control group,(1)there were widespread ALFF differences between groups throughout the left Inferior frontal gyrus,orbital part;right calcarine fissure and surrounding cortex;right anterior cingulate and paracingulate gyri;left thalamus;left inferior parietal,but supramarginal and angular gyri;right inferior parietal,but supramarginal and angular gyri and left paracentral lobule(P<0.05);(2)there were widespread DC differences between groups throughout the right inferior temporal gyrus;left inferior temporal gyrus;right anterior cingulate and paracingulate gyri;left superior frontal gyrus,medial orbital;left calcarine fissure and surrounding cortex;right fusiform gyrus;left inferior parietal,but supramarginal and angular gyri and left paracentral lobule(P<0.05).The combination of low-frequency amplitude and degree centrality has high application value in the judgment of brain neuronal activity and brain functional network changes in HM patients.

关 键 词：高度近视 静息态功能磁共振成像 低频振幅 度中心性 

分 类 号：R445.2[医药卫生—影像医学与核医学] R778.11[医药卫生—诊断学]