螺癸二烯酮合成方法学的研究进展  

Research Progress on Synthetic Methodology of Spirodecadienones

作　　者：刘天琦 高若楠 叶向彤 黄益 肖冰洁 胡名莉 何菱[1] LIU Tianqi;GAO Ruonan;YE Xiangtong;HUANG Yi;XIAO Bingjie;HU Mingli;HE Ling(West China School of Pharmacy,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《合成化学》2023年第10期818-839,共22页Chinese Journal of Synthetic Chemistry

基　　金：2021四川大学大学生创新创业项目(C2022119774)。

摘　　要：螺癸二烯酮衍生物具有独特的结构特征。季碳的螺原子作为二烯酮和五元杂环或碳环之间的桥梁,使其在三维立体空间上表现出特殊性。该结构单元不仅在有机化学中表现出独特的性质,而且还表现出多种生物活性,包括抗肿瘤活性、抗菌活性、抗炎活性、抗疟疾活性、抗肥胖活性和抗病毒活性等。本文综述了2-螺癸二烯酮衍生物和4-螺癸二烯酮衍生物,包括螺内酰胺、螺碳环和螺氧杂环的合成方法。有望为关于螺癸二烯酮衍生物的合成、新药开发或结构优化提供参考思路和方法借鉴。Spironadienone derivatives have unique structural characteristics.The spiro atoms of the quaternary carbon act as a bridge between dienone and five-membered heterocycle or carbocyclic,making it exhibit particularity in three-dimensional space.This structural unit not only exhibits unique properties in organic chemistry,but also exhibits a variety of biological activities,including anti-tumor activity,antibacterial activity,anti-inflammatory activity,antimalarial activity,anti-obesity activity,antiviral activity,etc.This paper reviews the synthetic methods of 2-spirodecylene ketone derivatives and 4-spirodecylene ketone derivatives including spirolactam,spiro carbocyclic and spiro oxygen heterocycle.It is hoped to provide reference ideas and methods for the synthesis,new drug development or structural optimization of spirodecylene ketone derivatives.

关 键 词：季碳 螺癸二烯酮衍生物 生物活性 合成方法 螺环 串联反应 过渡金属催化 

分 类 号：O622.4[理学—有机化学]