IL-22和IL-22 R1与MMP-9及MCP-1对感染性早产的诊断价值  

Diagnostic value of IL-22 and IL-22 R1,MMP-9 and MCP-1 in infectious preterm labor

作　　者：何胜悦 刘宇[1] 梁艳 张英[1] 李国芸[1] HE Sheng-yue;LIU Yu;LIANG Yan;ZHANG Ying;LI Guo-yun(Xinziang Central Hospital,Xinriang,Henan 453000,China)

机构地区：[1]新乡市中心医院产一科,河南新乡453000

出　　处：《中华医院感染学杂志》2023年第19期2999-3003,共5页Chinese Journal of Nosocomiology

基　　金：河南省医学科技攻关计划(联合共建)基金资助项目(LHGJ20191322)。

摘　　要：目的探讨白细胞介素-22(IL-22)、白细胞介素-22受体1(IL-22R1)、基质金属蛋白酶-9(MMP-9)、单核细胞趋化蛋白-1(MCP-1)对感染性早产的诊断价值.方法选择2019年12月-2022年12月于新乡市中心医院进行分娩产妇作为研究对象,根据其绒毛膜羊膜炎和早产情况,分别纳入感染性早产组(102例)、感染性足月产组(25例)、非感染性早产组(50例)、非感染性足月产组(196例);分析四组血清IL-22、IL-22 R1、MMP-9、MCP-1表达水平以及妊娠结局,绘制受试者工作特征(ROC)曲线分析血清指标单独及联合检测对感染性早产的预测价值.结果非感染性足月产组、非感染性早产组、感染性足月产组、感染性早产组血清IL-22、IL-22 R1、MMP-9、MCP-1水平呈升高趋势(P<0.05);将感染性早产纳入阳性,非感染性早产纳入阴性,绘制ROC曲线分析IL-22、IL-22R1、MMP-9、MCP-1单独及联合检测对感染性早产的预测价值,曲线下面积(AUC)为0.727、0.898、0.885、0.840和0.937;感染性早产组剖宫产发生率高于非感染性足月产组,产后出血发生率高于非感染性早产组、非感染性足月产组,新生儿肺炎发生率高于感染性足月产组、非感染性早产组、非感染性足月产组(P<0.05).结论感染性早产组产妇血清IL-22、IL-22 R1、MMP-9、MCP-1水平升高,检测产妇血清IL-22、IL-22 R1、MMP-9、MCP-1有助于感染性早产的诊断,进而制定有效、及时的干预措施,最终改善母婴结局.OBJECTIVE To investigate the diagnostic value of interleukin-22(IL-22),interleukin-22 receptor 1(IL-22R1),matrix metalloproteinase-9(MMP-9)and monocyte chemotactic protein-1(MCP-1)in infectious preterm labor.METHODS The parturients who delivered at Xinxiang Central Hospital from Dec.2019 to Dec.2022 were selected as the study subjects and included in the infective preterm delivery group(102 cases),the infective fullterm delivery group(25 cases),the non-infective preterm delivery group(50 cases)and the non-infective full-term delivery group(196 cases),respectively,according to their chorioamnionitis infection and preterm delivery.Serum IL-22,IL-22 R1,MMP-9,MCP-1 expression levels and pregnancy outcome were analyzed in the four groups,and the predictive value of serum indicators alone and in combination for infectious preterm delivery was analyzed by plotting receiver operating characteristic(ROC)curve.RESULTS Serum levels of IL-22,IL-22 R1,MMP-9 and MCP-1 in non-infectious term delivery group,non-infectious preterm delivery group,infectious term delivery group and infectious preterm delivery group were progressively increased(P<0.05).The ROC curves were plotted to analyze the predictive value of IL-22,IL-22R1,MMP-9 and MCP-1 alone and in combination for infectious preterm labour,The with an area under the curve(AUC)was 0.727,0.898,0.885,0.840 and 0.937,respectively,assuming that infected preterm birth was positive and non-infective preterm birth was negative.The incidence of cesarean section in infective preterm delivery group was higher than that in non-infective preterm delivery group,the incidence of postpartum hemorrhage was higher than that in non-infective preterm delivery group and non-infective full-term delivery group,and the incidence of neonatal pneumonia was higher than that in infective preterm delivery group,non-infective preterm delivery group and non-infective full-term delivery group(P<0.05).CONCLUSION Maternal serum IL-22,IL-22 R1,MMP-9 and MCP-1 levels increased in the infected preterm delivery

关 键 词：感染性早产 妊娠结局 白细胞介素-22 白细胞介素-22受体1 基质金属蛋白酶-9 单核细胞趋化蛋白-1 预测价值 

分 类 号：R714.21[医药卫生—妇产科学]