钙离子在巨噬细胞胞葬中的作用  

Role of Calcium Ions in Macrophage Efferocytosis

作　　者：卢娜[1] 蔡承衍 李志秀 朱俊帆 王宇 张腾 胡若洋 王现伟[1] LU Na;CAI Chengyan;LI Zhixiu;ZHU Junfan;WANG Yu;ZHANG Teng;HU Ruoyang;WANG Xianwei(Key Laboratory of Medical Tissue Regeneration,Xinxiang Medical College,Xinxiang 453003,China;School of Basic Medical Sciences,Xinxiang Medical College,Xinxiang 453003,China;Department of Cardiology,the First Affiliated Hospital of Xinxiang Medical College,Weihui 453100,China;Department of Endocrinology,Xinxiang Central Hospital,Xinxiang 453099,China;Department of Nephrology,Puyang People′s Hospital,Puyang 457005,China)

机构地区：[1]新乡医学院医用组织再生重点实验室,河南新乡453003 [2]新乡医学院基础医学院,河南新乡453003 [3]新乡医学院第一附属医院心内科,河南卫辉453100 [4]新乡市中心医院内分泌科,河南新乡453099 [5]濮阳市人民医院肾内科,河南濮阳457005

出　　处：《医学综述》2023年第13期2503-2508,共6页Medical Recapitulate

基　　金：国家自然科学基金(82270297);新乡医学院人才(博士)支持计划(XYBSKYZZ202136)。

摘　　要：机体通过专业和非专业的吞噬细胞执行胞葬功能以清除凋亡细胞,该过程包括识别结合凋亡细胞、形成吞噬小体、激活吞噬功能以及凋亡细胞最终被降解等,且该过程受多种因素的调控,在机体发育、维持组织稳态中具有重要作用。胞葬功能障碍可引起多种慢性炎症性及免疫性疾病。钙离子(Ca 2+)对维持细胞的胞葬功能具有关键作用,参与了巨噬细胞迁移、凋亡细胞识别、吞噬小体形成等步骤。提高胞质内Ca 2+浓度可促进胞葬功能,有望为胞葬功能障碍相关疾病提供新的治疗靶点。The body performs efferocytosis function through specialized and non-specialized phagocytes to remove apoptotic cells.This process includes identifying and binding apoptotic cells,forming phagosomes,activating phagocytosis,and ultimately degrading apoptotic cells,which is regulated by multiple factors and plays an important role in the body development and maintaining tissue homeostasis.Dysfunction of efferocytosis can lead to a variety of chronic inflammatory and immune diseases.Calcium ions(Ca 2+)play a key role in maintaining the efferocytosis of cells,participating in steps such as macrophage migration,apoptotic cell recognition,and phagocytic body formation.Increasing intracellular Ca 2+concentration can promote efferocytosis function and is expected to provide new therapeutic targets for diseases related to cellular burial dysfunction.

关 键 词：胞葬 巨噬细胞 凋亡细胞 钙离子 

分 类 号：R392.11[医药卫生—免疫学]