经典瞬时受体电位通道在心脏疾病中的研究进展  

Research Progress of Transient Receptor Potential Channel in Heart Diseases

作　　者：李俊豪 韩晗 谢东格 李寿田 LI Junhao;HAN Han;XIE Dongge;LI Shoutian(Department of Forensic Medicine,Zunyi Medical University,Zunyi 563006,China)

机构地区：[1]遵义医科大学法医学院,贵州遵义563006

出　　处：《医学综述》2023年第13期2526-2531,共6页Medical Recapitulate

基　　金：国家自然科学基金(81860060)。

摘　　要：瞬时受体电位通道(TRPC)作为一种与钾离子通道近似的阳离子内流通道,因其特殊的6次跨膜结构而具有非电压依赖特性,从而在细胞电生理活动中发挥重要作用。TRPC多表达于心脏、大脑、骨骼肌、血管平滑肌等人体内依赖电生理的器官和组织,TRPC通道功能异常可引发高血压、房性心律失常、阿尔茨海默病、肺动脉高压、心脏肥厚等疾病。因此,深入研究TRPC在心脏疾病中的作用机制,可以为寻找心脏疾病治疗的新靶点提供借鉴。The transient receptor potential channel(TRPC),as a cation influx channel similar to the potassium ion channel,plays an important role in cellular electrophysiological activities due to its unique 6-fold transmembrane structure and voltage independent characteristics.TRPC is mostly expressed in organs and tissues in the human body that rely on electrophysiology,such as the heart,brain,skeletal muscles,and vascular smooth muscles.Abnormal TRPC channel function can lead to diseases such as hypertension,atrial arrhythmias,Alzheimer′s disease,pulmonary hypertension,and cardiac hypertrophy.Therefore,intensive research of the mechanism of TRPC in cardiac diseases can provide a reference for finding new targets for the treatment of cardiac diseases.

关 键 词：心肌缺血再灌注 心肌肥大 心室重构 高血压 瞬时受体电位通道 

分 类 号：R541[医药卫生—心血管疾病]