蝎毒及其活性组分的抗肿瘤作用研究进展  

Research Progress in Anti-tumor Effects of Scorpion Venom and Its Active Components

作　　者：闵朗 吴学诚 董贤浩 田露刚 张树冰[3] MIN Lang;WU Xuecheng;DONG Xianhao;TIAN Lugang;ZHANG Shubing(Xiangya School of Medicine,Central South University,Changsha 410013,China;Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410013,China;School of Life Sciences,Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅医学院,长沙410013 [2]中南大学湘雅药学院,长沙410013 [3]中南大学生命科学学院,长沙410013

出　　处：《医学综述》2023年第13期2549-2555,共7页Medical Recapitulate

基　　金：国家自然科学基金(81972312);湖南省自然科学基金(2021JJ30912);国家级大学生创新创业训练计划(202110530039)。

摘　　要：蝎是地球上最古老的动物之一,蝎尾部毒囊分泌排出的蝎毒具有广泛的药理活性,在我国已有上千年的用药历史。蝎毒作为一种复杂的生物毒素,具有良好的抗肿瘤作用,包括抑制肿瘤细胞增殖和侵袭、诱导肿瘤细胞凋亡、抑制肿瘤血管生成等,目前已从不同蝎毒中纯化并鉴定出一系列具有抗肿瘤作用的活性组分,且其作用机制与靶点相继被阐明。深入研究蝎毒的化学成分及其活性组分的抗肿瘤作用和机制对蝎毒在抗肿瘤领域的研究及应用有重要的临床意义。Scorpion is one of the oldest animals on Earth.The scorpion venom secreted by the venom sac in the tail of the scorpion has a wide range of pharmacological activities,and has been used for thousands of years in China.Scorpion venom,as a complex biological toxin,has excellent anti-tumor effects,including inhibiting tumor cell proliferation and invasion,inducing tumor cell apoptosis,and inhibiting tumor angiogenesis.Currently,a series of active components with anti-tumor effects have been purified and identified from different scorpion venoms,and their mechanisms and targets have been elucidated in succession.Deeply studying the anti-tumor effects and mechanisms of scorpion venom′s chemical components and active components has important clinical significance for the research and application of scorpion venom in the anti-tumor field.

关 键 词：蝎毒 活性组分 抗肿瘤 机制 药用价值 

分 类 号：R285.5[医药卫生—中药学]