丙泊酚神经发育毒性的机制研究进展  

Research Progress on Mechanism of Neurodevelopmental Toxicity of Propofol

作　　者：周琰[1] 庄欣琪[3] 王晨旭[2] 于泳浩[2] ZHOU Yan;ZHUANG Xinqi;WANG Chenxu;YU Yonghao(Department of Radiotherapy,Tianjin Medical University General Hospital,Tianjin 300052,China;Department of Anesthesiology,Tianjin Medical University General Hospital,Tianjin 300052,China;Department of Anesthesiology,the Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津医科大学总医院放射治疗科,天津300052 [2]天津医科大学总医院麻醉科,天津300052 [3]天津医科大学第二附属医院麻醉科,天津300211

出　　处：《医学综述》2023年第13期2639-2645,共7页Medical Recapitulate

基　　金：天津市教委科研计划项目(2019KJ201)。

摘　　要：丙泊酚是一种常用的静脉麻醉药,在小儿麻醉中的应用逐渐增多。丙泊酚在发挥麻醉作用的同时可能对婴幼儿生长发育产生影响。丙泊酚的神经发育毒性可能涉及抑制神经干细胞存活与增生、影响突触发育和可塑性、钙超载和线粒体异常分裂等多种机制。因此,深入研究和评估丙泊酚对中枢神经系统发育的影响已成为目前麻醉领域的研究重点。未来,应充分认识丙泊酚的神经毒性作用,采取及时有效的预防和治疗措施,不断提高小儿麻醉安全性。Propofol is a commonly used intravenous general anesthesia agent and its application in pediatric anesthesia is increasing.While exerting anesthetic effect,propofol may also affect the growth of infants.The mechanisms of neurodevelopmental toxicity may involve decreasing neural stem cell survival and proliferation,disrupting dendrite development and plasticity,calcium overload and mitochondrial fission,etc.Therefore,further investigation and evaluation of propofol on the neurodevelopment has become a research focus in the field of anesthesia.In the future,the neurotoxic effect of propofol should be thoroughly understood,and timely and effective prevention and treatment measures should be given,to improve the safety of pediatric anesthesia constantly.

关 键 词：丙泊酚 神经发育 毒性 

分 类 号：R971.2[医药卫生—药品]