苦水玫瑰中重金属及有害元素ICP-MS测定  

Determination of Heavy Metals and Harmful Elements in Kushui Rose by ICP-MS

作　　者：王晓琳[1,2] 张平 马潇 刘志荣 李冬华 WANG Xiaolin;ZHANG Ping;MA Xiao;LIU Zhirong;LI Donghua(Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China;Gansu Provincial Academy of Chinese Medicine;Center for Inspection of Gansu Medical Products Administration/Gansu Center for Vaccine Inspection,Lanzhou 730070,China;Gansu Institute for Drug Control,Lanzhou 730070,China)

机构地区：[1]甘肃省中医院,甘肃兰州730050 [2]甘肃省中医药研究院,甘肃兰州730050 [3]甘肃省药品监督管理局审核查验中心/甘肃省疫苗检查中心,甘肃兰州730070 [4]甘肃省药品检验研究院,甘肃兰州730070

出　　处：《西部中医药》2023年第11期48-51,共4页Western Journal of Traditional Chinese Medicine

基　　金：甘肃省卫生行业科研计划项目(GSWSKY2018-50);甘肃省药品科研项目(2019GSMPA023);国家药监局中药材及饮片质量控制重点实验室项目(2020GSMPA-KL06-2);敦煌医学与转化教育部重点实验室2019年度开放课题(DHYX19-09)。

摘　　要：目的:建立苦水玫瑰中重金属汞(Hg)、铜(Cu)、铅(Pb)、镉(Cd)及有害元素砷(As)的电感耦合等离子体质谱(inductively coupled plasma mass spectrometry,ICP-MS)测定方法。方法:在苦水玫瑰样品中加硝酸进行微波消解处理,以72Ge、115In、209Bi为内标元素,采用ICP-MS法检测甘肃多个产地苦水玫瑰中Pb、Cd、AS、Hg、Cu元素。结果:所测定苦水玫瑰中5种元素线性关系良好,相关系数r≥0.9984,各元素检出限为0.0049~10.3473 ng/mL,定量限为0.0163~34.4909 ng/mL;所检测甘肃不同产地20批苦水玫瑰样品中Pb、Cd、AS、Hg、Cu元素含量均在安全范围内,其中Cd、Hg未检出。结论:建立的苦水玫瑰中重金属及有害元素ICP-MS测定方法具有灵敏度高、准确性好、便于操作等特点,适用于苦水玫瑰中重金属及有害元素的检测分析,该方法的建立为苦水玫瑰质量标准草案的形成提供了实验数据支撑。Objective:To establish the methods of determining five kinds of heavy metals,and the harmful elements including Pb,cd,As,Hg,Cu in Kushui rose by ICP-MS.Methods:After microwave ablation of the samples with nitric acid,72Ge,115In and 209Bi as internal standard elements,ICP-MS was applied to detect the contents of Pb,cd,As,Hg,Cu in Kushui rose from from different producing areas of Gansu.Results:Five heavy metals in the tested samples of Kushui rose showed good linear relationship,and the correlation coefficient r≥0.9984,the detection limit of each element ranged from 0.0049 to 10.3473 ng/mL,the quantitative detection between 0.0163 and 34.4909 ng/mL;the contents of Pb,cd,As,Hg and Cu in 20 batches of the samples from different producing areas of Gansu were within the safe range,among which,Cd and Hg weren't found.Conclusion:The ICP-MS method for the determination of five heavy metals and the harmful elements,possessing the characteristics of high sensitivity,good accuracy and convenient operation,is suitable for the detection and analysis of heavy metals and harmful elements in Kushui rose,which could provide experimental data support for the formation of the draft of quality standard of Kushui rose.

关 键 词：苦水玫瑰 微波消解 电感耦合等离子体质谱 重金属元素 

分 类 号：R282.71[医药卫生—中药学]