多指标综合评分优选金荞麦胶囊提取工艺  

Study on the Extraction Process of Jinqiaomai Capsules by Multi-index Comprehensive Evaluation

作　　者：童晓东[1] 马焙焙[1] 彭敏[1] TONG Xiaodong;MA Beibei;PENG Min(Nantong Hospital of Traditional Chinese Medicine/Nantong Hospital Affiliated to Nanjing University of Chinese Medicine,Nantong 226001,China)

机构地区：[1]南通市中医院/南京中医药大学南通附属医院,江苏南通226001

出　　处：《西部中医药》2023年第11期57-60,共4页Western Journal of Traditional Chinese Medicine

基　　金：2019年度南通市市级科技计划(指导性)项目(JCZ19099)。

摘　　要：目的:优选金荞麦胶囊的提取工艺。方法:以没食子酸、原儿茶酸、儿茶素、原花青素B2、表儿茶素、得膏率进行多指标考察,以提取时间、乙醇用量、乙醇浓度等多因素进行正交试验设计,采用综合评分方法优选最佳提取工艺。结果:以回流时间1.5 h,加10倍量浓度为55%的乙醇为最优提取工艺。结论:此最佳提取工艺成本低,可靠稳定,简便,有效成分提取率高,可用于金荞麦胶囊的提取工艺。Objective:To optimize the extraction process of Jinqiaomai(Fagopyri dibotryis rhizoma)capsules.Methods:Multi-index investigation was performed using using gallic acid,protocatechuic acid,catechin,procyanidin B2,epicatechin and the rate of ointment,and the orthogonal experiment was conducted based on multiple factors such as extraction time,ethanol dosage,and ethanol concentration,and the optimal extraction process is optimized by multi-index comprehensive evaluation.Results:The optimal extraction process was the reflux time of 1.5 hours and the addition of 10 times the amount of 55%ethanol.Conclusion:The best extraction methods,low cost,reliable,stable,simple and high extraction of active ingredients,could be used for the extraction of Jinqiaomai capsules.

关 键 词：金荞麦胶囊 多指标综合评分 正交试验 提取工艺 

分 类 号：R283.6[医药卫生—中药学]