脊髓损伤中不同时间段自噬及相关信号通路的研究进展  

Research Progress of Autophagy and Related Signaling Pathways at Different Time Periods in Spinal Cord Injury

作　　者：焦子远 许明[1] 卓越 展立芬 向晶 张泓[1] JIAO Ziyuan;XU Ming;ZHUO Yue;ZHAN Lifen;XIANG Jing;ZHANG Hong(Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学,长沙410208

出　　处：《医学综述》2023年第20期4017-4021,共5页Medical Recapitulate

基　　金：国家自然科学基金(82274666,82205255);湖南省自然科学基金(2022JJ40312,2022JJ30036);湖南省教育厅科学研究项目(20A363)。

摘　　要：脊髓损伤(SCI)是一种临床常见的神经疾病,伤后致残率高,严重损害患者身心健康。SCI后的病理生理过程复杂,目前尚未完全阐明,但可能与自噬密切相关。其中,与自噬相关的哺乳动物雷帕霉素靶蛋白、磷脂酰肌醇-3-激酶、AMP活化的蛋白激酶等信号通路等均可能参与SCI后不同时间段的病理生理过程,但目前关于SCI后不同时间段自噬及相关信号通路发挥的调控作用尚存在争议。因此,深入研究SCI后不同时间段自噬以及相关信号通路的具体作用机制,可以为SCI的治疗提供新思路。Spinal cord injury(SCI)is a common clinical neurological disease with a high post-injury disability rate,which seriously impairs the physical and mental health of the patients.The pathophysiological processes after SCI are complex and have not been fully elucidated yet,but may be closely related to autophagy.Among them,mammalian target of rapamycin,phosphoinositide-3-kinase,AMP-activated protein kinase and other signaling pathways related to autophagy may be involved in the pathophysiological process at different time periods after SCI,but there is still controversy about the regulatory roles played by autophagy and the related signaling pathways at different time periods after SCI.Therefore,an in-depth study of the specific mechanisms of autophagy and related signaling pathways at different time periods after SCI may provide new ideas for the treatment of SCI.

关 键 词：脊髓损伤 自噬 信号通路 

分 类 号：R651.2[医药卫生—外科学]