基于微生态学的儿童功能性便秘与肥胖相关性的研究进展  

Research Progress in Microecology-based Association between Functional Constipation and Obesity in Children

作　　者：余繁荣 王伟 闫玉琴 苏少晨[1,2] YU Fanrong;WANG Wei;YAN Yuqin;SU Shaochen(School of Stomatology,Lanzhou University,Lanzhou 730030,China;Health Examination Center,the First Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学口腔医学院,兰州730030 [2]兰州大学第一医院健康体检中心,兰州730030

出　　处：《医学综述》2023年第20期4028-4033,共6页Medical Recapitulate

基　　金：甘肃省陇原青年创新创业人才(团队)项目(2022LQTD57)。

摘　　要：近年来儿童肥胖和功能性便秘(FC)的患病率逐渐升高,严重影响患儿健康。儿童肥胖与FC的发生密切相关,且存在多个相互重叠的因素,如肠道菌群失调以及受肠道菌群影响的脂多糖、胆汁酸、5-羟色胺和短链脂肪酸等信号通路均与儿童肥胖和FC的发生密切相关。但目前关于儿童FC与肥胖的临床预防和治疗方面的研究仍存在许多问题,且两者的相关性也尚未明确。因此,未来深入研究FC与肥胖的相关性,可以为疾病的治疗提供新思路。In recent years,the prevalence of obesity and functional constipation(FC)in children has gradually increased,which seriously affects the health of the children.It is believed that childhood obesity is closely related to the occurrence of FC,and there are many overlapping factors,such as the dysregulation of intestinal flora and the information pathways of lipopolysaccharide,bile acids,5-hydroxytryptamine and short-chain fatty acids affected by intestinal flora,all closely related to childhood obesity and FC.However,there are still many problems in the clinical prevention and treatment of FC and obesity in children,and the correlation between the two is not clear.Therefore,the in-depth study of the correlation between FC and obesity in the future can provide new ideas for the treatment of the diseases.

关 键 词：功能性便秘 肥胖 肠道菌群 代谢产物 

分 类 号：R721[医药卫生—儿科]