2型糖尿病合并脑梗死患者血清LP-PLA2、MMP-9水平与颈动脉斑块易损性的关系  

Relationship of Serum LP-PLA2 and MMP-9 Levels with the Vulnerability of Carotid Plaque in Patients with Type 2 Diabetes and Cerebral Infarction

作　　者：沈佳 钱朵朵 张珏[1] 孙健 王运九 SHEN Jia;QIAN Duoduo;ZHANG Jue(Department of Laboratory Medicine,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai,201203)

机构地区：[1]上海中医药大学附属曙光医院检验科,上海201203 [2]同济大学附属杨浦医院检验科,上海201203

出　　处：《医学临床研究》2023年第10期1485-1488,共4页Journal of Clinical Research

摘　　要：【目的】探讨2型糖尿病(T2DM)合并脑梗死(CI)患者血清脂蛋白相关磷脂酶A2(LP-PLA2)、基质金属蛋白酶-9(MMP-9)水平与颈动脉斑块易损性的关系。【方法】收集两院收治的115例T2DM合并CI患者的临床资料,统计患者颈动脉斑块发生情况,分析影响T2DM合并CI患者颈动脉斑块易损性的因素及患者血清LP-PLA2、MMP-9水平预测颈动脉易损斑块的价值。【结果】115例T2DM合并CI患者中有64例(55.65%)为易损斑块,剩余51例(44.35%)为稳定斑块。Logistic多因素回归分析显示:LP-PLA2(OR:4.600,95%CI:1.893~11.179)、MMP-9(OR:3.931,95%CI:1.618~9.555)、低密度脂蛋白胆固醇(LDL-C)(OR:4.067,95%CI:1.674~9.885)水平是影响T2DM合并CI患者颈动脉斑块稳定性的独立因素(P<0.05)。受试者工作特征(ROC)曲线分析显示,血清LP-PLA2、MMP-9及二者联合预测T2DM合并CI患者易损斑块的曲线下面积(AUC)分别为0.786、0.721和0.884。【结论】T2DM合并CI患者颈动脉存在易损斑块的风险较高,LP-PLA2联合MMP-9预测其颈动脉易损斑块的效能良好。【Objective】To explore the relationship of serum lipoprotein-related phospholipase A2(LP-PLA2)and matrix metalloproteinase-9(MMP-9)levels with the vulnerability of carotid plaque in patients with type 2 diabetes(T2DM)and cerebral infarction(CI).【Methods】Clinical data of 115 patients of T2DM combined with CI were collected.The occurrence of carotid artery plaques in patients with T2DM and CI were counted.Factors affecting the vulnerability of carotid plaque in patients with T2DM and CI were analyzed.The value of serum LP-PLA2 and MMP-9 in T2DM patients combined with CI in predicting vulnerable carotid plaque was analyzed as well.【Results】Among 115 patients with T2DM and CI,64(55.65%)were vulnerable plaques,and the remaining 51(44.35%)were stable plaques.Logistic multivariate regression analysis showed that levels of LP-PLA2(OR:4.600,95%CI:1.893~11.179),MMP-9(OR:3.931,95%CI:1.618~9.555)and low-density lipoprotein cholesterol(LDL-C,OR:4.067,95%CI:1.674~9.885)were independent factors affecting the stability of carotid plaque in patients with T2DM and CI(P<0.05).ROC curve analysis showed that serum LP-PLA2,MMP-9 and the combination of the two for predicting the AUC of vulnerable plaques in patients with T2DM and CI were 0.786,0.721 and 0.884,respectively.【Conclusion】T2DM patients with CI have a high risk of vulnerable plaque in the carotid artery,and LP-PLA2 combined with MMP-9 has a good predictive effect on the vulnerable plaque in the carotid artery.

关 键 词：糖尿病 2型/并发症 脑梗死/并发症 1-烷基-2-乙酰甘油磷酸胆碱酯酶/血液 基质金属蛋白酶9/血液 颈动脉狭窄 

分 类 号：R587.1[医药卫生—内分泌]