滋养细胞自噬对胎盘形成不良致胎儿生长受限的作用研究进展  

Research Progress of Trophoblast Autophagy in Fetal Growth Restriction Due to Poor Placentation

作　　者：李小卉 陈奕[1] LI Xiaohui;CHEN Yi(Department of Perinatal Medicine,Beijing Obstetrics and Gynecology Hospital,Capital Medical University.Beijing Maternal and Child Health Care Hospital,Beijing 100026,China)

机构地区：[1]首都医科大学附属北京妇产医院/北京妇幼保健院围产医学部,北京100026

出　　处：《医学综述》2023年第12期2321-2326,共6页Medical Recapitulate

摘　　要：胎儿生长受限(FGR)指胎儿未达到其应有的生长发育潜能,是导致围生儿患病及死亡的重要原因,其最终的病理致病途径大多为绒毛血管生成障碍和子宫胎盘灌注不良,但具体机制不明,且尚无有效治疗措施。自噬是机体在应激状态下的适应性反应,在维持细胞内环境稳态中起重要作用,自噬障碍可通过影响细胞应激、细胞死亡、细胞衰老、细胞免疫及长链非编码RNA等途径引起胎盘形成不良,进一步导致FGR。因此,探索自噬对胎盘形成的影响可为揭示FGR的发生机制、寻找新的诊疗靶点提供思路。Fetal growth restriction(FGR)refers to the failure of the fetus to achieve its expected growth and development potential,which is an important cause of perinatal illness and death.Its ultimate pathological pathways are mostly disorders of villous angiogenesis and poor uterine placental perfusion,but the specific mechanism is unknown and there is no effective treatment measure yet.Autophagy is an adaptive response of the body under stress,and plays an important role in maintaining the homeostasis of the intracellular environment.Autophagy disorder can cause placental dysplasia by affecting cell stress,cell death,cell aging,cellular immunity and long chain non-coding RNA,and further lead to FGR.Therefore,exploring the impact of autophagy on placental formation can provide insights for revealing the mechanism of FGR and finding new targets for FGR diagnosis and treatment.

关 键 词：胎儿生长受限 自噬 滋养细胞 胎盘形成 

分 类 号：R714.25[医药卫生—妇产科学]