慢性肾脏病患者并发脑血管病的类型及相关危险因素  

Research Progress in Types and Risk Factors of Cerebrovascular Diseases in Patients with Chronic Kidney Disease

作　　者：朱艾琳 李银平[1] ZHU Ailin;LI Yinping(Department of Nephrology,Xuanwu Hospital of Capital Medical University,Beijing 100053,China;Capital Medical University First Clinical School,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院肾科,北京100053 [2]首都医科大学第一临床医学院,北京100053

出　　处：《医学综述》2023年第12期2401-2406,共6页Medical Recapitulate

基　　金：首都医科大学本科生科研创新项目(XSKY2021320)。

摘　　要：脑血管病(CVD)是慢性肾脏病(CKD)重要的并发症,也是CKD患者致残致死的重要原因。CKD并发CVD的危险因素主要分为传统危险因素(高龄、高血压、糖尿病、高脂血症等)和非传统危险因素(尿毒症毒素、钙磷代谢紊乱、肾性贫血、氧化应激、高同型半胱氨酸血症、蛋白尿、肾小球滤过率降低、营养不良、内皮功能不全、血管钙化等),上述各种危险因素导致CKD并发CVD的类型和影响机制也不同,而病因学分析有助于CKD患者并发CVD的一级预防与后续治疗。Cerebrovascular disease(CVD)is an important complication of chronic kidney disease(CKD)and a major cause of disability and death in CKD patients.The risk factors of CKD complicated with cerebrovascular disease mainly include traditional risk factors(old age,hypertension,diabetes,hyperlipidemia,etc.)and non-traditional risk factors(uremic toxin,calcium and phosphorus metabolism disorder,renal anemia,oxidative stress,hyperhomocysteinemia,proteinuria,reduced glomerular filtration rate,malnutrition,endothelial dysfunction,vascular calcification,etc.).The above risk factors lead to different types and mechanisms of CKD complicated with CVD,and etiology analysis is helpful for the primary prevention and follow-up treatment of CKD patients complicated with CVD.

关 键 词：慢性肾脏病 脑血管病 脑梗死 脑出血 

分 类 号：R692.5[医药卫生—泌尿科学]