脂肪来源干细胞抑制瘢痕疙瘩的研究进展  

Research Progress of Adipose-derived Stem Cells in Inhibiting Keloids

作　　者：张慧 尹从洋 谢林海[2] ZHANG Hui;YIN Congyang;XIE Linhai(Gannan Medical University,Ganzhou 341000,China;Department of Plastic Surgery,the First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China)

机构地区：[1]赣南医学院,江西赣州341000 [2]赣南医学院第一附属医院整形外科,江西赣州341000

出　　处：《医学综述》2023年第15期2941-2945,2952,共6页Medical Recapitulate

基　　金：江西省卫生计生委科技计划(20195398)。

摘　　要：瘢痕疙瘩是指以无自限性持续生长为特征的病理性瘢痕,是整形外科领域的难题之一。目前,针对瘢痕疙瘩的治疗,尚无被广泛采纳的金标准。基于细胞治疗的再生医学成为目前的研究热点,脂肪来源干细胞(ADSCs)在脂肪组织中储存量大、增殖能力强,可通过相对较小的侵入性方式获得,伦理学上相对无争议。探索ADSCs抑制瘢痕疙瘩可能的机制发现,ADSCs及其衍生物可以促进组织的高质量愈合、重塑胶原、减少纤维化,认为其是一项具有前景的瘢痕疙瘩干预措施。Keloids are pathological scars characterized by unlimited,sustained growths and are one of the challenges in the field of plastic surgery.Currently,there is no widely adopted gold standard for the treatment of keloids.Regenerative medicine based on cell therapy has become a research hotspot.Adipose-derived stem cells(ADSCs)have large storage in adipose tissue and strong proliferative capacity,and can be obtained in a relatively small invasive way,which is relatively uncontroversial ethically.By exploring the possible mechanism of ADSCs inhibiting keloids,ADSCs and their derivatives were found to be able to promote high-quality tissue healing,remodel collagen,and reduce fibrosis,making them a promising intervention of keloids.

关 键 词：瘢痕疙瘩 脂肪来源干细胞 炎症细胞因子 血管生成 伤口愈合 

分 类 号：R622[医药卫生—整形外科]