瑞舒伐他汀联合单硝酸异山梨酯片治疗冠心病心绞痛的临床疗效  

Rosuvastatin Combined with Isosorbide Mononitrate Tablets on Angina Pectoris of Coronary Heart Disease

作　　者：芦伟 刘满意 方勇[1] LU Wei;LIU Manyi;FANG Yong(Department of Cardiovascular Medicine,Wanbei Coal-electricity Group General Hospital,Suzhou 234000,China)

机构地区：[1]皖北煤电集团总医院心血管内科,安徽宿州234000

出　　处：《医学综述》2023年第15期3116-3120,共5页Medical Recapitulate

摘　　要：目的探讨瑞舒伐他汀联合单硝酸异山梨酯片治疗冠心病心绞痛患者的临床疗效。方法选择2021年4月至2022年10月在皖北煤电集团总医院接受经皮冠状动脉介入治疗的90例冠心病心绞痛患者作为研究对象,根据治疗方案不同分为对照组(44例)和观察组(46例)。对照组采用瑞舒伐他汀(每次10 mg、每日1次)治疗,观察组在对照组基础上联合单硝酸异山梨酯片(每次20 mg,每日2次)治疗,两组均连续治疗3个月。比较两组患者心绞痛发作及用药情况,临床疗效,治疗前后心功能[左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)]、血脂[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]水平,以及用药期间不良反应发生情况。结果观察组心绞痛发作频率、硝酸甘油使用频率低于对照组(P<0.01),硝酸甘油消耗量明显少于对照组(P<0.01),心绞痛发作持续时间短于对照组(P<0.01)。观察组临床总有效率高于对照组[95.65%(44/46)比77.27%(34/44)](χ^(2)=6.574,P=0.010)。治疗后,两组患者LVESD、LVEDD均较治疗前降低,LVEF较治疗前升高(P<0.05),且观察组LVESD、LVEDD低于对照组[(25.3±1.8)mm比(34.2±1.5)mm、(44.4±1.7)mm比(49.2±1.9)mm],LVEF高于对照组[(59.6±3.6)%比(54.2±4.4)%](P<0.01)。治疗后,两组患者TC、TG、LDL-C均较治疗前降低(P<0.05),HDL-C较治疗前升高(P<0.05),且观察组TC、TG、LDL-C低于对照组[(2.30±0.55)mmol/L比(3.68±0.64)mmol/L、(1.33±0.47)mmol/L比(2.11±0.32)mmol/L、(2.50±0.55)mmol/L比(3.75±0.53)mmol/L],HDL-C高于对照组[(1.87±0.50)mmol/L比(1.36±0.49)mmol/L](P<0.01)。对照组和观察组不良反应总发生率分别为11.36%(5/44)、15.22%(7/46),差异无统计学意义(P>0.05)。结论瑞舒伐他汀联合单硝酸异山梨酯片治疗冠心病心绞痛的临床疗效显著,可改善患者心功能、血脂水平,减少心绞痛发作,且不显著增加不�Objective To investigate the effects of rosuvastatin combined with isosorbide mononitrate for angina pectoris in patients with coronary heart disease.Methods A total of 90 patients with angina pectoris of coronary heart disease who received percutaneous coronary intervention in Wanbei Coal-electricity Group General Hospital from Apr.2021 to Oct.2022 were included.They were divided into a control group(44 cases)and an observation group(46 cases)according to different treatment plans.The control group was treated with rosuvastatin(10 mg each time,once a day),and the observation group was treated with isosorbide mononitrate tablets(20 mg each time,twice a day)on the basis of the control group′s regimen.Both groups were treated continuously for 3 months.The angina pectoris attack and drug use,clinical efficacy,cardiac function[left ventricular end systolic dimension(LVESD),left ventricular end diastolic dimension(LVEDD),left ventricular ejection fraction(LVEF)],blood lipid[total cholesterol(TC),triacylglycerol(TG),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C)]levels before and after treatment of the two groups were compared,as well as the occurrence of adverse reactions during medication.Results The frequency of angina pectoris attack and the frequency of nitroglycerin use in the observation group were lower than those in the control group(P<0.01),the consumption of nitroglycerin was significantly lower than that in the control group(P<0.01),and the duration of angina pectoris attack was shorter than that in the control group(P<0.01).The total effective rate of the observation group was higher than that of the control group[95.65%(44/46)vs 77.27%(34/44)](χ^(2)=6.574,P=0.010).After treatment,LVESD and LVEDD decreased and LVEF increased in both groups compared with before treatment(P<0.05).The LVESD and LVEDD in the observation group were lower than those in the control group[(25.3±1.8)mm vs(34.2±1.5)mm,(44.4±1.7)mm vs(49.2±1.9)mm],LVEF was higher than that of the control

关 键 词：冠心病 心绞痛 瑞舒伐他汀 单硝酸异山梨酯片 

分 类 号：R541.4[医药卫生—心血管疾病]