龙血竭紫草油膏联合曲安奈德治疗瘢痕疙瘩的临床疗效  

Clinical Efficacy of Resina Draconis and Shikonin Ointment Combined with Triamcinolone Acetonide in Treatment of Keloid

作　　者：杨庆燕[1] 毕文倩[1] 王帅 李娜[1] YANG Qingyan;BI Wenqian;WANG Shuai;LI Na(Department of Medical Cosmetology,Cangzhou Hospital of Integrated Traditional Chinese Medicine-Western Medicine of Hebei,Cangzhou 061000,China)

机构地区：[1]河北省沧州中西医结合医院医疗美容科,河北沧州061000

出　　处：《医学综述》2023年第16期3309-3313,共5页Medical Recapitulate

基　　金：河北省中医药管理局科研计划项目(2022235)。

摘　　要：目的探讨龙血竭紫草油膏联合曲安奈德治疗瘢痕疙瘩的临床疗效。方法选取2021年1—7月河北省沧州中西医结合医院收治的104例瘢痕疙瘩患者作为研究对象,采用随机数字表法分为对照组和观察组,每组52例。其中,对照组采用曲安奈德治疗,瘢痕疙瘩内及瘢痕下方肌内注射剂量为0.2~0.4 ml/cm 3,每月注射1次,共治疗5个月;观察组在对照组的基础上采用龙血竭紫草油膏治疗,每日2次,连续治疗5个月。比较两组的临床疗效,治疗前后的温哥华瘢痕量表(VSS)评分、视觉模拟评分法(VAS)评分和相关血清指标[转化生长因子-β1(TGF-β1)、基质金属蛋白酶2(MMP-2)]变化,及不良反应发生和随访6个月的复发情况。结果观察组的总有效率高于对照组[88.46%(46/52)比71.15%(37/52)](P<0.05)。治疗后,两组的VSS、VAS评分均较治疗前降低(P<0.05),且观察组低于对照组[3.0(3.0,3.0)分比4.5(4.0,5.0)分、1.0(1.0,1.0)分比1.5(1.0,2.0)分](P<0.01)。治疗后,两组的血清TGF-β1、MMP-2水平均较治疗前明显降低(P<0.05),且观察组低于对照组[(17.2±2.2)μg/L比(19.2±2.2)μg/L、(289±19)μg/L比(319±17)μg/L](P<0.01)。两组的总不良反应发生率比较差异无统计学意义(P>0.05);随访6个月,观察组的复发率低于对照组[7.69%%(4/52)比23.08%(12/52)](P<0.05)。结论龙血竭紫草油膏联合曲安奈德治疗瘢痕疙瘩临床疗效显著,可改善患者的瘢痕状况,减轻疼痛程度,降低复发率,且不会增加不良反应。Objective To investigate the efficacy of resina draconis and shikonin ointment combined with triamcinolone acetonide in the treatment of keloid.Methods A total of 104 patients with keloid admitted to Cangzhou Hospital of Integrated Traditional Chinese Medicine-Western Medicine of Hebei from Jan.2021 to Jul.2021 were included.According to the method of random number table,they were divided into a control group and an observation group,with 52 cases each.the control group was treated with intramuscular injection dose of 0.2-0.4 ml/cm 3 Triamcinolone acetonide into and under keloid,once a month for 5 months.On the basis of control group,the observation group was treated with Resina draconis and shikonin ointment,twice a day,for 5 months.The clinical efficacy,changes of Vancouver scar scale(VSS)score,visual analogue scale(VAS)score and related serum indexes[transforming growth factor-β1(TGF-β1),matrix metalloproteinase-2(MMP-2)]before and after treatment,occurrence of adverse reactions and recurrence after 6 months of follow-up were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group[88.46%(46/52)vs 71.15%(37/52)](P<0.05).After treatment,the VSS and VAS scores of the two groups were lower than those before treatment(P<0.05),and the observation group was lower than the control group[3.0(3.0,3.0)vs 4.5(4.0,5.0),1.0(1.0,1.0)vs 1.5(1.0,2.0)](P<0.01).After treatment,the serum levels of TGF-β1 and MMP-2 in the two groups were significantly lower than those before treatment(P<0.05),and the observation group was lower than the control group[(17.2±2.2)μg/L vs(19.2±2.2)μg/L,(289±19)μg/L vs(319±17)μg/L](P<0.01).There was no statistical significant difference in the incidence of total adverse reactions between the two groups(P>0.05).After 6 months of follow-up,the recurrence rate of the observation group was lower than that of the control group[7.69%(4/52)vs 23.08%(12/52)](P<0.05).Conclusion Resina draconis and shikonin ointment combined w

关 键 词：瘢痕疙瘩 龙血竭紫草油膏 曲安奈德 温哥华瘢痕量表评分 复发 

分 类 号：R619.6[医药卫生—外科学]