PAQosome各亚基的基本功能研究概况  

Overview of Basic Functions of PAQosome Subunits

作　　者：石榴 韩铭[2] 袁晓雪 叶峰[1] 成军[2] 蔺淑梅[1] SHI Liu;HAN Ming;YUAN Xiaoxue;YE Feng;CHENG Jun;LIN Shumei(Department of Infectious Disease Medicine,the First Hospital of Xi′an Jiaotong University,Xi′an 710061,China;Department of Infectious Disease Research Center,Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]西安交通大学第一附属医院感染科,西安710061 [2]首都医科大学附属地坛医院传染病研究所,北京100015

出　　处：《医学综述》2023年第18期3549-3554,共6页Medical Recapitulate

基　　金：国家艾滋病和病毒性肝炎等重大传染病防治科技专项(2017ZX10201201,2017ZX10202202);国家重点研发计划“精准医学研究”重点专项(2017YFC0908100)。

摘　　要：PAQosome可协助热激蛋白90组装大量的大型多亚基蛋白复合物,并参与蛋白质合成、核糖体生物发生、转录、剪接等基本细胞功能。目前,PAQosome各亚基作用的相关研究主要集中在肿瘤方面,其在多数肿瘤中上调,且与肿瘤的发生、发展、预后密切相关。此外,其还与阿尔茨海默病的发生、淋巴细胞和生殖细胞的发育、纤维化的形成有关,而上述功能的实现依赖于PAQosome各亚基的功能差异。因此,深入认识PAQosome各亚基的基本功能有助于进一步指导后续PAQosome在非肿瘤疾病中功能的研究。PAQosome(particle for arrangement of quaternary structure)can assist heat shock protein 90 to assemble a large number of large multi-subunit protein complexes,which participate in protein synthesis,ribosome biogenesis,transcription,splicing and other basic cellular functions.Currently,the majority of functional studies on the PAQosome subunits are focused on tumors.The majority of tumors have an up-regulated PAQosome,which is directly correlated with the occurrence,growth,and prognosis of tumors.Besides,PAQosome also plays a role in the development of Alzheimer′s disease,controls the growth of lymphocytes and germ cells,and influences the formation of fibrosis.The realization of these functions depends on the functional differences of different subunits of PAQosome.Therefore,in-depth understanding of the rbasic function of PAQosome subunits is helpful to further guiding of the subsequent research of PAQosome function in non-neoplastic diseases.

关 键 词：PAQosome 前折叠亚单位 p53和DNA损伤调控分子1 非常规预折叠RNA聚合酶Ⅱ亚基5相互作用体 伴侣样普遍表达的预折叠蛋白 天冬酰胺合成酶结构域1上游开放读码框 

分 类 号：R34[医药卫生—基础医学]