新型支气管肺发育不良病理机制相关生物标志物的研究进展  

Research Progress of Biomarkers Related to Pathological Mechanism of New Type of Bronchopulmonary Dysplasia

作　　者：白晓婷 梅花[2] BAI Xiaoting;MEI hua(Inner Mongolia Medical University,Hohhot 010000,China;Department of Neonatology,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000,China)

机构地区：[1]内蒙古医科大学,呼和浩特010000 [2]内蒙古医科大学附属医院新生儿科,呼和浩特010000

出　　处：《医学综述》2023年第18期3563-3567,3574,共6页Medical Recapitulate

基　　金：内蒙古自治区自然科学基金(2020MS08034)。

摘　　要：支气管肺发育不良(BPD)是一种早产儿常见的慢性呼吸系统疾病,严重影响早产儿的神经发育和远期生存质量。目前,关于BPD不良生物标志物的研究多以肺损伤、肺部炎症等经典型BPD特征为主。随着围生医学的发展,经典型BPD逐渐被新型BPD取代。新型BPD的组织病理学特征以肺泡发育阻滞和肺微血管畸形为主要特点,但其发病机制尚未完全阐明。因此,探寻可早期预测新型BPD的生物标志物成为该领域的研究热点,以尽可能地指导临床应用上述生物标志物早期识别、早期干预存在BPD高危因素的早产儿,并为早期预防BPD提供依据。Bronchopulmonary dysplasia(BPD)is a common chronic respiratory disease in premature infants,which seriously affects their neurological development and long-term quality of life.At present,research on the biological markers of BPD mainly focuses on classic BPD features such as lung injury and inflammation.With the development of perinatal medicine,classic BPD is gradually being replaced by new BPD.The histopathological features of the novel BPD are mainly characterized by pulmonary alveolar developmental arrest and pulmonary microvascular malformations,but its pathogenesis has not been fully elucidated.Therefore,exploring biomarkers that can predict novel BPD in the early stage has become a research hotspot in this field,in order to guide the clinical application of these biomarkers in early identification,early intervention of premature infants with high-risk factors for BPD,and provide a basis for early prevention of BPD.

关 键 词：支气管肺发育不良 生物标志物 氧化应激 信号转导通路 细胞外基质 

分 类 号：R722.6[医药卫生—儿科]